COIL - coilin Gene

Homo sapiens

Also known as CLN80; p80-coilin

Gene ID: 8161 | Gene type: protein coding

About COIL

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,938,199-56,961,050 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Broad expression in testis (RPKM 65.0), thyroid (RPKM 8.3) and 22 other tissues.

Summary

The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

COIL Products(1)

mRNA	Protein	Name
NM_004645.3	NP_004636.1	coilin

Protein Preferred Names

Protein Names

coilin

coilin p80

Related Diseases

Diseases

Alias

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Actinomycosis

Actinomycetoma	Boil
Canaliculitis	Actinomycotic Infection
Actinomycotic Madura Foot	Keratoactinomycosis
Furuncle	Actinomycotic Mycetema
Actinomycotic Mycetoma Of Foot	Madura Foot Due To Actinomadura
Actinomyces Israeli	Actinomycetes
Anaerobic Actinomyces Infection	Actinomycotic Infection Of Unspecified Site
Actinomycosis Nos	Actinomycotic Node
Actinomyces Infection	Actinomycotic Mycetoma
Mycetoma Due To Filamentous Bacteria

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Differentiating Neuroblastoma

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10996A	KHS101 hydrochloride		99.84%	Unkown
HY-135960	BO-264		99.63%	Unkown
HY-18990	GSK180736A	Inhibitor	98.01%	Unkown
HY-118837	WF-536	Inhibitor	/	Unkown
HY-150536	EP39	Inhibitor	/	Unkown
HY-RS02958	COIL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COIL	RGD	RGD:62031
Felis catus	COIL	VGNC	VGNC:61051
Mus musculus	COIL	MGD	MGI:104842
Bos taurus	COIL	VGNC	VGNC:27552
Canis familiaris	COIL	VGNC	VGNC:39454
Others	COIL	NCBI

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