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COIL - coilin Gene

Also Known as CLN80; p80-coilin

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8161

About COIL

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,938,199-56,961,050 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Broad expression in testis (RPKM 65.0), thyroid (RPKM 8.3) and 22 other tissues.

Summary

The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

COIL Products (1)

mRNA	Protein	Name
NM_004645.3	NP_004636.1	coilin

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12757932	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	12757932	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12757932	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12757932	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19734146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
coilin	coilin p80

COIL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COIL	P38432	ZNF277	Homo sapiens	Q8WWA6	Y2H Array	25416956
Intra	COIL	P38432	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	COIL	P38432	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	COIL	P38432	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	COIL	P38432	ADAMTS12	Homo sapiens	P58397-3	Validated Y2H	32296183
Intra	COIL	P38432	PDE4D	Homo sapiens	Q08499	Y2H Prey Pooling	25416956
Intra	COIL	P38432	PDE4D	Homo sapiens	Q08499	Validated Y2H	25416956
Intra	COIL	P38432	VRK1	Homo sapiens	Q99986	Anti Tag CoIP	21920476
Intra	COIL	P38432	VRK1	Homo sapiens	Q99986	Peptide Array	21920476
Intra	COIL	P38432	VRK1	Homo sapiens	Q99986	Confocal	21920476
Intra	COIL	P38432	ANKS1B	Homo sapiens	Q7Z6G8-2	Anti Tag CoIP	15862129
Intra	COIL	P38432	ANKS1B	Homo sapiens	Q7Z6G8-2	Pull Down	15862129
Intra	COIL	P38432	ANKS1B	Homo sapiens	Q7Z6G8-1	Anti Bait CoIP	15862129
Intra	COIL	P38432	ANKS1B	Homo sapiens	Q7Z6G8-1	Pull Down	15862129
Intra	COIL	P38432	DYNC2I2	Homo sapiens	Q96EX3	Validated Y2H	25416956
Intra	COIL	P38432	ARMCX1	Homo sapiens	Q9P291	Validated Y2H	25416956
Intra	COIL	P38432	ARMCX1	Homo sapiens	Q9P291	Y2H Array	25416956
Intra	COIL	P38432	AK6	Homo sapiens	Q9Y3D8	Anti Tag CoIP	16079131
Intra	COIL	P38432	AK6	Homo sapiens	Q9Y3D8	Y2H	16079131
Intra	COIL	P38432	AK6	Homo sapiens	Q9Y3D8	Pull Down	16079131
Intra	COIL	P38432	C9orf72	Homo sapiens	Q96LT7	Validated Y2H	32296183
Intra	COIL	P38432	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	COIL	P38432	XRCC6	Homo sapiens	P12956	Pull Down	21070772
Intra	COIL	P38432	PSME3	Homo sapiens	P61289	Y2H Array	16713569
Intra	COIL	P38432	PSME3	Homo sapiens	P61289	Validated Y2H	32296183
Intra	COIL	P38432	PSME3	Homo sapiens	P61289	Y2H	16713569
Intra	COIL	P38432	SNRPF	Homo sapiens	P62306	Validated Y2H	32296183
Intra	COIL	P38432	SNRPF	Homo sapiens	P62306	Y2H Array	25416956
Intra	COIL	P38432	XRCC5	Homo sapiens	P13010	Pull Down	21070772
Intra	COIL	P38432	XRCC5	Homo sapiens	P13010	Competition Binding	21070772
Intra	COIL	P38432	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	COIL	P38432	POLR2L	Homo sapiens	P62875	Validated Y2H	25416956
Intra	COIL	P38432	POLR2L	Homo sapiens	P62875	Y2H Array	25416956
Intra	COIL	P38432	NKAPD1	Homo sapiens	Q6ZUT1	Validated Y2H	32296183
Intra	COIL	P38432	SMN1	Homo sapiens	Q16637	Anti Bait CoIP	21072240
Intra	COIL	P38432	SMN1	Homo sapiens	Q16637	Pull Down	21070772
Intra	COIL	P38432	POLR3C	Homo sapiens	Q9BUI4	Validated Y2H	32296183
Intra	COIL	P38432	SRPK2	Homo sapiens	P78362	Validated Y2H	32296183
Intra	COIL	P38432	FGF12	Homo sapiens	P61328	Y2H Prey Pooling	25416956
Intra	COIL	P38432	PTS	Homo sapiens	Q03393	Y2H Array	25416956
Intra	COIL	P38432	PTS	Homo sapiens	Q03393	Y2H Prey Pooling	25416956
Intra	COIL	P38432	PTS	Homo sapiens	Q03393	Validated Y2H	25416956
Intra	COIL	P38432	DRG1	Homo sapiens	Q9Y295	Y2H Array	25416956
Intra	COIL	P38432	NFU1	Homo sapiens	Q9UMS0	Validated Y2H	32296183
Intra	COIL	P38432	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	16713569
Intra	COIL	P38432	CEP70	Homo sapiens	Q8NHQ1	Y2H	16713569
Intra	COIL	P38432	LNX1	Homo sapiens	Q8TBB1	Pull Down	16713569
Intra	COIL	P38432	PDLIM5	Homo sapiens	Q96HC4	Y2H Array	31515488
Intra	COIL	P38432	PDLIM5	Homo sapiens	Q96HC4	Y2H Prey Pooling	25416956
Intra	COIL	P38432	PDLIM5	Homo sapiens	Q96HC4	Y2H Array	25416956
Intra	COIL	P38432	PICK1	Homo sapiens	Q9NRD5	Y2H	16713569
Intra	COIL	P38432	PDE4D	Homo sapiens	Q08499-8	Validated Y2H	32296183
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253-1	IF	12757932

Cross: Cross-species interaction Intra: Intraspecies interaction

COIL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82787	Coilin Antibody (YA2532)	WB	Human
HY-P82787A	Coilin Antibody (YA2532)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Actinomycosis	Actinomycetoma Boil Canaliculitis Actinomycotic Infection Actinomycotic Madura Foot Keratoactinomycosis Furuncle Actinomycotic Mycetema Actinomycotic Mycetoma Of Foot Madura Foot Due To Actinomadura Actinomyces Israeli Actinomycetes Anaerobic Actinomyces Infection Actinomycotic Infection Of Unspecified Site Actinomycosis Nos Actinomycotic Node Actinomyces Infection Actinomycotic Mycetoma Mycetoma Due To Filamentous Bacteria
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Differentiating Neuroblastoma
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148808	Zelasudil	Inhibitor	99.48%	Phase 2

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5423	GALA	Inducer	99.04%	Unkown
HY-135960	BO-264		99.76%	Unkown
HY-18990	GSK180736A	Inhibitor	98.81%	Unkown
HY-146331	PC190723	Inhibitor	98.67%	Unkown
HY-B0178B	6M Guanidine hydrochloride Solution		98.0%	Unkown
HY-N8671	Withanoside V	Inhibitor	99.9%	Unkown
HY-P11455A	Lipopeptide CPE4 TFA		98.69%	Unkown
HY-P11456A	Lipopeptide CPK4 TFA		98.92%	Unkown
HY-118046	GSK2163632A	Inhibitor	/	Unkown
HY-118837	WF-536	Inhibitor	/	Unkown
HY-150536	EP39	Inhibitor	/	Unkown
HY-174386	STAT3-IN-43	Inhibitor	/	Unkown
HY-182098	DSPE-PEG1000-GALA		/	Unkown
HY-182098A	DSPE-PEG2000-GALA		/	Unkown
HY-182098B	DSPE-PEG3400-GALA		/	Unkown
HY-182098C	DSPE-PEG5000-GALA		/	Unkown
HY-P10820	N36Mut(e,g)	Inhibitor	/	Unkown
HY-P11455	Lipopeptide CPE4		/	Unkown
HY-P11456	Lipopeptide CPK4		/	Unkown
HY-RS02958	COIL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21316	Coil Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27835	Coil Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COIL	RGD	RGD:62031
Felis catus	COIL	VGNC	VGNC:61051
Mus musculus	COIL	MGD	MGI:104842
Bos taurus	COIL	VGNC	VGNC:27552
Canis familiaris	COIL	VGNC	VGNC:39454
Others	COIL	NCBI