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SNRPF - small nuclear ribonucleoprotein polypeptide F Gene

Also Known as SMF; Sm-F; snRNP-F

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6636

About SNRPF

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:95,858,952-95,866,140 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 26.2), colon (RPKM 24.6) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in spliceosomal snRNP assembly. Located in cytosol and nucleus. Part of several cellular components, including methylosome; nucleus; and pICln-Sm protein complex. Biomarker of nasopharynx carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

SNRPF Products (2)

mRNA	Protein	Name
NM_001394209.1	NP_001381138.1	small nuclear ribonucleoprotein F isoform 2
NM_003095.5	NP_003086.1	small nuclear ribonucleoprotein F isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IMP IMP: Inferred from mutant phenotype	7744013	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9417867	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA splicing	IMP IMP: Inferred from mutant phenotype	7744013	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SMN-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U4 snRNP	IDA IDA: Inferred from direct assay	21516107	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of U7 snRNP	IDA IDA: Inferred from direct assay	11574479	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
part of methylosome	IDA IDA: Inferred from direct assay	18984161	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA
part of pICln-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of small nuclear ribonucleoprotein complex	IDA IDA: Inferred from direct assay	11991638	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	7744013	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPF Protein Structure

LSM

0
86 a.a.

Protein Preferred Names	Protein Names
small nuclear ribonucleoprotein F	sm protein F

SNRPF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNRPF	P62306	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	SNRPF	P62306	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	SNRPF	P62306	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	SNRPF	P62306	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SNRPF	P62306	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	SNRPF	P62306	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SNRPF	P62306	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	28514442
Intra	SNRPF	P62306	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	OSBPL2	Homo sapiens	Q9H1P3	Validated Y2H	32296183
Intra	SNRPF	P62306	SNRPD2	Homo sapiens	P62316	Y2H Array	32296183
Intra	SNRPF	P62306	SNRPD2	Homo sapiens	P62316	Y2H Prey Pooling	32296183
Intra	SNRPF	P62306	SNRPD2	Homo sapiens	P62316	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	SNRPD2	Homo sapiens	P62316	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	SNRPD2	Homo sapiens	P62316	Y2H	9417867
Intra	SNRPF	P62306	SNRPD2	Homo sapiens	P62316	Y2H	22365833
Intra	SNRPF	P62306	SNRPD2	Homo sapiens	P62316	Anti Tag CoIP	28514442
Intra	SNRPF	P62306	SNRPD2	Homo sapiens	P62316	Validated Y2H	32296183
Intra	SNRPF	P62306	SNRPE	Homo sapiens	P62304	Y2H Array	32296183
Intra	SNRPF	P62306	SNRPE	Homo sapiens	P62304	Y2H Prey Pooling	32296183
Intra	SNRPF	P62306	SNRPE	Homo sapiens	P62304	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	LSM3	Homo sapiens	P62310	Validated Y2H	32296183
Intra	SNRPF	P62306	LSM3	Homo sapiens	P62310	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	LSM7	Homo sapiens	Q9UK45	Validated Y2H	32296183
Intra	SNRPF	P62306	LSM7	Homo sapiens	Q9UK45	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	32296183
Intra	SNRPF	P62306	LSM7	Homo sapiens	Q9UK45	Y2H Array	32296183
Intra	SNRPF	P62306	LSM5	Homo sapiens	Q9Y4Y9	MAPPIT	25416956
Intra	SNRPF	P62306	LSM5	Homo sapiens	Q9Y4Y9	Y2H Prey Pooling	25416956
Intra	SNRPF	P62306	LSM5	Homo sapiens	Q9Y4Y9	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	32296183
Intra	SNRPF	P62306	LSM5	Homo sapiens	Q9Y4Y9	Y2H Array	25416956
Intra	SNRPF	P62306	LSM6	Homo sapiens	P62312	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	LSM6	Homo sapiens	P62312	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	GEMIN2	Homo sapiens	O14893	Y2H Array	32296183
Intra	SNRPF	P62306	GEMIN2	Homo sapiens	O14893	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	GEMIN2	Homo sapiens	O14893	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	GEMIN2	Homo sapiens	O14893	Y2H Prey Pooling	32296183
Intra	SNRPF	P62306	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	28514442
Intra	SNRPF	P62306	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	SNRPF	P62306	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	SNRPF	P62306	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	SNRPF	P62306	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	SNRPF	P62306	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	SNRPF	P62306	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	SNRPF	P62306	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	SNRPF	P62306	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	28514442
Intra	SNRPF	P62306	SNRPA1	Homo sapiens	P09661	Y2H	22365833
Intra	SNRPF	P62306	SNRPA1	Homo sapiens	P09661	Anti Tag CoIP	35271311
Intra	SNRPF	P62306	SNRPA1	Homo sapiens	P09661	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	SNRPA1	Homo sapiens	P09661	Anti Tag CoIP	28514442
Intra	SNRPF	P62306	COIL	Homo sapiens	P38432	Anti Tag CoIP	33961781
Intra	SNRPF	P62306	COIL	Homo sapiens	P38432	Y2H Array	32296183
Intra	SNRPF	P62306	COIL	Homo sapiens	P38432	Y2H Prey Pooling	25416956
Intra	SNRPF	P62306	COIL	Homo sapiens	P38432	Y2H Prey Pooling	32296183
Intra	SNRPF	P62306	COIL	Homo sapiens	P38432	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13509	SNRPF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNRPF	MGD	MGI:1917128
Rattus norvegicus	SNRPF	RGD	RGD:1588229
Bos taurus	SNRPF	VGNC	VGNC:35081
Others	SNRPF	NCBI