2. Gene
  3. SF3A2 - splicing factor 3a subunit 2 Gene

SF3A2 - splicing factor 3a subunit 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PRP11; SAP62; PRPF11; SF3a66

Gene ID: 8175 | Gene type: protein coding

About SF3A2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,236,824-2,248,655 (from NCBI)

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 28.5), ovary (RPKM 22.4) and 25 other tissues.

Summary

This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

SF3A2 Products(1)

mRNA Protein Name
NM_007165.5 NP_009096.2 splicing factor 3A subunit 2

SF3A2 Protein Structure

zf-met

zf-met: Zinc-finger of C2H2 type (54 - 78)

  • 0
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  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

splicing factor 3A subunit 2

SAP 62

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12758 SF3A2 Human Pre-designed siRNA Set A / Unkown
HY-RS12761 SF3B2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SF3A2 MGD MGI:104912
Rattus norvegicus SF3A2 RGD RGD:1308627
Felis catus SF3A2 VGNC VGNC:65053
Bos taurus SF3A2 VGNC VGNC:34507
Macaca mulatta SF3A2 VGNC VGNC:77178
Canis familiaris SF3A2 VGNC VGNC:46068