SF3A3 - splicing factor 3a subunit 3 Gene

Homo sapiens

Also known as PRP9; PRPF9; SAP61; SF3a60

Gene ID: 10946 | Gene type: protein coding

About SF3A3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,956,975-37,990,022 (from NCBI)

This gene has 8 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 22.5), lymph node (RPKM 20.6) and 25 other tissues.

Summary

This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

SF3A3 Products(2)

mRNA	Protein	Name
NM_001320830.2	NP_001307759.1	splicing factor 3A subunit 3 isoform 2
NM_006802.4	NP_006793.1	splicing factor 3A subunit 3 isoform 1

SF3A3 Protein Structure

SF3a60_bindingd

Telomere_Sde2_2

DUF3449

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

splicing factor 3A subunit 3

SAP 61

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12759	SF3A3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS12762	SF3B3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SF3A3	VGNC	VGNC:97824
Felis catus	SF3A3	VGNC	VGNC:65054
Mus musculus	SF3A3	MGD	MGI:1922312
Rattus norvegicus	SF3A3	RGD	RGD:1308726
Bos taurus	SF3A3	VGNC	VGNC:34508

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