2. Gene
  3. TRIM69 - tripartite motif containing 69 Gene

TRIM69 - tripartite motif containing 69 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Trif; HSD34; RNF36; HSD-34

Gene ID: 140691 | Gene type: protein coding

About TRIM69

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:44,736,528-44,767,827 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 119 orthologues and 80 paralogues. Biased expression in testis (RPKM 19.8) and brain (RPKM 1.8).

Summary

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces Apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

TRIM69 Products(5)

mRNA Protein Name
NM_001301144.2 NP_001288073.1 E3 ubiquitin-protein ligase TRIM69 isoform c
NM_001301145.2 NP_001288074.1 E3 ubiquitin-protein ligase TRIM69 isoform d
NM_001301146.2 NP_001288075.1 E3 ubiquitin-protein ligase TRIM69 isoform e
NM_080745.5 NP_542783.2 E3 ubiquitin-protein ligase TRIM69 isoform b
NM_182985.5 NP_892030.3 E3 ubiquitin-protein ligase TRIM69 isoform a

TRIM69 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (41 - 81)

PRY

PRY: SPRY-associated domain (325 - 373)

SPRY

SPRY: SPRY domain (375 - 481)

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Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM69

RFP-like domain-containing protein trimless

Related Diseases

Diseases Alias
Multisystem Inflammatory Syndrome In Children

Mis-C

Multisystem Inflammatory Disorder In Children And Adolescents

Paediatric Inflammatory Multisystemic Syndrome

Mic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15068 TRIM69 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TRIM69 VGNC VGNC:54380
Macaca mulatta TRIM69 VGNC VGNC:79096
Felis catus TRIM69 VGNC VGNC:66551
Rattus norvegicus TRIM69 RGD RGD:1305074
Mus musculus TRIM69 MGD MGI:1918178
Bos taurus TRIM69 VGNC VGNC:36350
Others TRIM69 NCBI