ASNS - asparagine synthetase (glutamine-hydrolyzing) Gene

Also Known as TS11; ASNSD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 440

About ASNS

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:97,851,677-97,928,441 (from NCBI)

This gene has 17 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 19.6), testis (RPKM 14.4) and 24 other tissues.

Summary

The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

ASNS Products (7)

mRNA Protein Name
NM_001178075.2 NP_001171546.1 asparagine synthetase [glutamine-hydrolyzing] isoform b
NM_001178076.2 NP_001171547.1 asparagine synthetase [glutamine-hydrolyzing] isoform c
NM_001178077.1 NP_001171548.1 asparagine synthetase [glutamine-hydrolyzing] isoform c
NM_001352496.2 NP_001339425.1 asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_001673.5 NP_001664.3 asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_133436.3 NP_597680.2 asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_183356.4 NP_899199.2 asparagine synthetase [glutamine-hydrolyzing] isoform a

ASNS Protein Structure

GATase_7

GATase_7: Glutamine amidotransferase domain (49 - 164)

Asn_synthase

Asn_synthase: Asparagine synthase (235 - 467)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 561 a.a.
Protein Preferred Names Protein Names

asparagine synthetase [glutamine-hydrolyzing]

  • TS11 cell cycle control protein

ASNS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ASNS P08243 TRIM69 Homo sapiens Q86WT6-2
Validated Y2H
32296183
Intra
ASNS P08243 TRIM69 Homo sapiens Q86WT6-2
Y2H Array
32296183
Intra
ASNS P08243 TRIM69 Homo sapiens Q86WT6-2
Y2H Prey Pooling
32296183
Intra
ASNS P08243 TRIM69 Homo sapiens Q86WT6
Y2H Prey Pooling
25416956
Intra
ASNS P08243 TRIM69 Homo sapiens Q86WT6
Y2H Array
25416956
Intra
ASNS P08243 WDR27 Homo sapiens A2RRH5
Validated Y2H
25416956
Intra
ASNS P08243 WDR27 Homo sapiens A2RRH5
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

ASNS Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P80550 Asparagine Synthetase Antibody (YA608) WB, IHC-P Human, Rat
HY-P80550A Asparagine Synthetase Antibody (YA608)(PBS only) WB, IHC-P Human, Rat

Related Diseases

Diseases Alias
Asparagine Synthetase Deficiency

  • Asns Deficiency

  • ASNSD

  • Congenital Microcephaly-Severe Encephalopathy-Progressive Cerebral Atrophy Syndrome

  • Disorder Of Asparagine Metabolism

  • Congenital Microcephaly - Severe Encephalopathy - Progressive Cerebral Atrophy Syndrome
Neuronal Migration Disorders

  • Abnormality Of Neuronal Migration

  • Malformations Of Cortical Development, Group Ii

  • Neuronal Dysmigration Syndromes
Childhood Acute Lymphocytic Leukemia

  • Childhood Acute Lymphoblastic Leukemia

  • Childhood All

  • Pediatric Acute Lymphoblastic Leukemia

  • Lymphoblastic Leukemia Acute Childhood
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Precursor T-Cell Acute Lymphoblastic Leukemia

  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia
Adult Hepatocellular Carcinoma

  • Adult Primary Hepatocellular Carcinoma

  • Adult Hepatoma

  • Adult Hcc
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Hyperekplexia

  • Hereditary Hyperekplexia

  • Kok Disease

  • Congenital Stiff Man Syndrome

  • Familial Startle Disease

  • Sthe

  • Stiff-Baby Syndrome

  • Hereditary Hyperexplexia

  • Startle Disease

  • Exaggerated Startle Reaction

  • Hyperexplexia Hereditary

  • Startle Disease, Familial

  • Startle Reaction, Exaggerated

  • Stiff-Man Syndrome, Congenital

  • Stiff-Person Syndrome, Congenital

  • Congenital Stiff-Man Syndrome

  • Congenital Stiff-Person Syndrome

  • Familial Hyperekplexia

  • Startle Syndrome

  • Stiff Baby Syndrome

  • Hyperekplexia, Hereditary

  • Stiff-Person Syndrome
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (7)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-132254 Sacituzumab govitecan Inhibitor 99.13% Unkown
HY-132254A Sacituzumab govitecan (solution) Inhibitor 99.19% Unkown
HY-N0667 L-Asparagine 99.78% Unkown
HY-W017443 L-Asparagine monohydrate 99.77% Unkown
HY-14874 Topiroxostat Inhibitor 99.06% Unkown
HY-123319 Antofloxacin hydrochloride Inhibitor / Unkown
HY-123319A Antofloxacin Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-103018 Gusacitinib Inhibitor 99.63% Phase 2
HY-136579 ASN007 Inhibitor 99.48% Phase 1
HY-160196 HC-7366 Inhibitor 99.58% Phase 1
HY-164457 ASN-001 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (128)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-128946 CL2A-SN-38 99.97% Unkown
HY-128923 SKF-34288 hydrochloride Inhibitor 98.61% Unkown
HY-W002327 Fmoc-Asn(Trt)-OH 99.96% Unkown
HY-136626 Z-Ala-Ala-Asn-AMC 99.28% Unkown
HY-108625 SHA 68 Antagonist 99.84% Unkown
HY-112205A RR-11a analog Inhibitor 99.12% Unkown
HY-164668 ADC Control Human IgG1-SN-38 97.53% Unkown
HY-P4385 (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) Antagonist 99.77% Unkown
HY-N0667S2 L-Asparagine-15N2 monohydrate 99.95% Unkown
HY-139147 iHCK-37 Inhibitor 99.52% Unkown
HY-175282 ASX-173 98.47% Unkown
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2 99.55% Unkown
HY-136579A ASN007 benzenesulfonate Inhibitor 99.72% Unkown
HY-W010378 D-Asparagine 98.0% Unkown
HY-156586 Egalognastat Inhibitor 99.03% Unkown
HY-N9446 H-Asn(glcnac-beta-D)-OH 98.65% Unkown
HY-P1341 OXA(17-33) 97.48% Unkown
HY-P1043A NGR peptide Trifluoroacetate 98.91% Unkown
HY-N0667S3 L-Asparagine-13C4 monohydrate 98.9% Unkown
HY-W009085 Fmoc-Asn-OH 99.19% Unkown
HY-W017443S L-Asparagine-13C4,15N2 monohydrate 98.0% Unkown
HY-111323 ASN06917370 99.23% Unkown
HY-128111 ASN02563583 Activator 99.21% Unkown
HY-B1803A Tracazolate hydrochloride Modulator 99.24% Unkown
HY-E70068 Endo-β-N-acetylglucosaminidase (Endo S) / Unkown
HY-N0667S5 L-Asparagine-d3 hydrate 99.64% Unkown
HY-113667 ASN04885796 Activator 99.40% Unkown
HY-148393 G0 N-glycan-Asn 99.95% Unkown
HY-P11200 γ-Glu-Asn 98.12% Unkown
HY-W013330 3′-Deoxyguanosine 97.0% Unkown
HY-P4279 Ovalbumin (154-159) Inhibitor 99.18% Unkown
HY-125028 Hck-IN-1 Inhibitor 98.10% Unkown
HY-150242A Cbz-Ala-Ala-Asn TFA 99.54% Unkown
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% Unkown
HY-162238 OSM-S-106 Inhibitor 99.34% Unkown
HY-150787 BMS-986339 99.74% Unkown
HY-128128 ASN04421891 Modulator 99.00% Unkown
HY-131092A H-Asn-Arg-OH diTFA 99.83% Unkown
HY-175282A (2S,3R,4S)-ASX-173 Control 99.29% Unkown
HY-P10485 Glp-Asn-Pro-AMC 99.26% Unkown
HY-P1809A Velmupressin acetate Agonist 99.47% Unkown
HY-P1962 β-Secretase inhibitor Inhibitor 98.06% Unkown
HY-W010378R D-Asparagine (Standard) 99.90% Unkown
HY-129360A Ala-Ala-Asn-PAB TFA / Unkown
HY-141464 Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH 95.03% Unkown
HY-156314 ASN 07115873 Inhibitor 98.76% Unkown
HY-172473 DSPE-PEG2000-NGR 95.0% Unkown
HY-176977 Exatecan-mpGly-Asn-Asn-(βAla) 96.25% Unkown
HY-180467 Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me / Unkown
HY-180467A Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium / Unkown
HY-78162 cis-3-Hydroxyproline Substrate 95.0% Unkown
HY-N0667S L-Asparagine-13C4,15N2,d8 99% Unkown
HY-N0667S1 L-Asparagine-15N2,d8 / Unkown
HY-P3882 Fmoc-Ala-Glu-Gln-Lys-NH2 99.26% Unkown
HY-W008233 Z-Asn-OH 98.76% Unkown
HY-W017443S1 L-Asparagine-amide-15N monohydrate 99.80% Unkown
HY-148389 Disialo-Asn 98.04% Unkown
HY-W017443S2 L-Asparagine-13C4,15N2,d3 monohydrate 99.90% Unkown
HY-W142294 Ac-D-Asn-OH / Unkown
HY-P1809 Velmupressin Agonist / Unkown
HY-P1810 c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm Agonist / Unkown
HY-103018A Gusacitinib hydrochloride Inhibitor / Unkown
HY-P1043 NGR peptide 99.73% Unkown
HY-103018S Gusacitinib-d4 / Unkown
HY-113761 ASN03576800 Inhibitor 99.61% Unkown
HY-122179 NUCC-555 Antagonist / Unkown
HY-128947 CL2 Linker / Unkown
HY-129360 Ala-Ala-Asn-PAB / Unkown
HY-129361 Fmoc-Ala-Ala-Asn-PABC-PNP / Unkown
HY-130933 Fmoc-Ala-Ala-Asn(Trt)-OH 99.80% Unkown
HY-131463 ASN-1377642 Antagonist / Unkown
HY-136733 Ac-DNLD-CHO Inhibitor / Unkown
HY-139245 MC-Ala-Ala-Asn-PAB / Unkown
HY-141149 Fmoc-PEG4-Ala-Ala-Asn-PAB / Unkown
HY-141150 Azido-PEG5-Ala-Ala-Asn-PAB / Unkown
HY-141151 Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB / Unkown
HY-144628 Fmoc-Asn-Pro-Val-PABC-PNP 99.34% Unkown
HY-144629 Asn-Pro-Val-PABC-MMAE TFA / Unkown
HY-144630 diSPhMC-Asn-Pro-Val-PABC-MMAE / Unkown
HY-148031 MC-Ala-Ala-Asn-PAB-PNP / Unkown
HY-148392 Neu5Gcα(2-6) N-Glycan-Asn / Unkown
HY-149360 P-gb-IN-1 Inhibitor / Unkown
HY-149825 MTHFD2-IN-1 Inhibitor / Unkown
HY-149826 MTHFD2-IN-2 Inhibitor / Unkown
HY-149827 MTHFD2-IN-3 Inhibitor / Unkown
HY-149828 MTHFD2-IN-4 Inhibitor / Unkown
HY-149828A MTHFD2-IN-4 sodium Inhibitor / Unkown
HY-151146 (1R,3S)-THCCA-Asn Inhibitor / Unkown
HY-172472 DSPE-PEG1000-NGR / Unkown
HY-172473A DSPE-PEG3400-NGR / Unkown
HY-172474 DSPE-PEG5000-NGR / Unkown
HY-174223 α-Glucosidase-IN-90 Inhibitor / Unkown
HY-183362 Antileishmanial agent-42 Inhibitor / Unkown
HY-185461 Mc-Asn-Asn-E104 Agonist / Unkown
HY-185462 Mc-Asn-Asn / Unkown
HY-E71264 β-Acetylglucosaminidase 18A, Bacteroides thetaiotaomicron / Unkown
HY-N0667S4 L-Asparagine-4-13C monohydrate / Unkown
HY-N0667S7 L-Asparagine-13C4,15N2 / Unkown
HY-N15365 Antcin B Inhibitor / Unkown
HY-P11408 [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) Agonist / Unkown
HY-P11620 H-Asn-Pro-Glu-Tyr(PO3H2)-OH / Unkown
HY-P1610 Asudemotide Inducer / Unkown
HY-P2212 (Asn1,Val5)-Angiotensin II / Unkown
HY-P2397 Fmoc-Asn(Trt)-Thr(psi(Me,Me)pro)-OH / Unkown
HY-P2401 Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH / Unkown
HY-P3220 [D-Asn5]-Oxytocin Activator / Unkown
HY-P3615 [Asn18] Endothelin-1 (swine, human) Agonist / Unkown
HY-P3716 H(-Asn-Pro-Asn-Ala)2-OH / Unkown
HY-P4019 Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 / Unkown
HY-P4407 (D-Asn28)-Exenatide Control / Unkown
HY-P4919 Mca-SEVNLDAEFK(Dnp) / Unkown
HY-P5415 DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS / Unkown
HY-RS01098 ASNS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W017443S3 L-Asparagine-15N2,d3 monohydrate / Unkown
HY-W017443S4 L-Asparagine-1,2,3,4-13C4 monohydrate / Unkown
HY-W091365 Boc-Asn(Xan)-OH / Unkown
HY-W845197 L-Asparagine-15N2 / Unkown
HY-118731 TNK-6123 Activator / Unkown
HY-129286 ASN 05397535 / Unkown
HY-131092 H-Asn-Arg-OH / Unkown
HY-141152 Azido-PEG4-Ala-Ala-Asn(Trt)-PAB / Unkown
HY-141153 Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP / Unkown
HY-151829 Fmoc-L-Asn(EDA-N3)-OH / Unkown
HY-157338 NHS-Ala-Ala-Asn-active metabolite Inhibitor / Unkown
HY-RS19117 Asns Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25607 Asns Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W002327S Fmoc-Asn(Trt)-OH-13C4,15N2 96.9% Unkown
HY-W173361 CBP/p300-IN-24 Inhibitor / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P992184 Anti-5T4 scFv-Fc Antibody / Unkown
HY-P991497 ASN-500 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ASNS RGD RGD:2162
Mus musculus ASNS MGD MGI:1350929
Macaca mulatta ASNS VGNC VGNC:80798
Felis catus ASNS VGNC VGNC:69354
Canis familiaris ASNS VGNC VGNC:53542
Others ASNS NCBI