ASNS - asparagine synthetase (glutamine-hydrolyzing) Gene

Homo sapiens

Also known as TS11; ASNSD

Gene ID: 440 | Gene type: protein coding

About ASNS

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:97,851,677-97,928,441 (from NCBI)

This gene has 17 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 19.6), testis (RPKM 14.4) and 24 other tissues.

Summary

The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

ASNS Products(7)

mRNA	Protein	Name
NM_001178075.2	NP_001171546.1	asparagine synthetase [glutamine-hydrolyzing] isoform b
NM_001178076.2	NP_001171547.1	asparagine synthetase [glutamine-hydrolyzing] isoform c
NM_001178077.1	NP_001171548.1	asparagine synthetase [glutamine-hydrolyzing] isoform c
NM_001352496.2	NP_001339425.1	asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_001673.5	NP_001664.3	asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_133436.3	NP_597680.2	asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_183356.4	NP_899199.2	asparagine synthetase [glutamine-hydrolyzing] isoform a

ASNS Protein Structure

GATase_7

Asn_synthase

0
100
200
300
400
500
561 a.a.

Protein Preferred Names

Protein Names

asparagine synthetase [glutamine-hydrolyzing]

TS11 cell cycle control protein

Recombinant ASNS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78974	Asparagine Synthetase/ASNS Protein, Human (HEK293, His)	P08243-1 (C2-A561)	≥95%

Related Diseases

Diseases

Alias

Asparagine Synthetase Deficiency

Asns Deficiency	ASNSD
Congenital Microcephaly-Severe Encephalopathy-Progressive Cerebral Atrophy Syndrome	Disorder Of Asparagine Metabolism
Congenital Microcephaly - Severe Encephalopathy - Progressive Cerebral Atrophy Syndrome

Neuronal Migration Disorders

Abnormality Of Neuronal Migration	Malformations Of Cortical Development, Group Ii
Neuronal Dysmigration Syndromes

Childhood Acute Lymphocytic Leukemia

Childhood Acute Lymphoblastic Leukemia	Childhood All
Pediatric Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia Acute Childhood

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14874	Topiroxostat	Inhibitor	99.63%	Unkown
HY-123319	Antofloxacin hydrochloride	Inhibitor	/	Unkown
HY-123319A	Antofloxacin	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-103018	Gusacitinib	Inhibitor	99.41%	Phase 2

Pre-clinical Phase

Bioactive Molecules (63)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128946	CL2A-SN-38		99.07%	Unkown
HY-136579	ASN007	Inhibitor	99.02%	Unkown
HY-128923	SKF-34288 hydrochloride	Inhibitor	≥95.0%	Unkown
HY-112205A	RR-11a analog	Inhibitor	99.12%	Unkown
HY-108625	SHA 68	Antagonist	98.11%	Unkown
HY-114174	Fmoc-Ala-Glu-Asn-Lys-NH2		99.62%	Unkown
HY-139147	iHCK-37	Inhibitor	99.69%	Unkown
HY-W002327	Fmoc-Asn(Trt)-OH		99.96%	Unkown
HY-136579A	ASN007 benzenesulfonate	Inhibitor	98.06%	Unkown
HY-156586	ASN90		99.63%	Unkown
HY-P4385	(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)	Antagonist	98.56%	Unkown
HY-P1043A	NGR peptide Trifluoroacetate		98.06%	Unkown
HY-125028	Hck-IN-1	Inhibitor	98.53%	Unkown
HY-W010378	D-Asparagine		≥98.0%	Unkown
HY-111323	ASN06917370		99.23%	Unkown
HY-141464	Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH		95.03%	Unkown
HY-B1803A	Tracazolate hydrochloride	Modulator	99.03%	Unkown
HY-W008233	Z-Asn-OH		98.30%	Unkown
HY-W009085	Fmoc-Asn-OH		99.17%	Unkown
HY-128111	ASN02563583		99.21%	Unkown
HY-129360A	Ala-Ala-Asn-PAB TFA		/	Unkown
HY-150242A	Cbz-Ala-Ala-Asn TFA		99.54%	Unkown
HY-N9446	H-Asn(glcnac-beta-D)-OH		98.65%	Unkown
HY-P3882	Fmoc-Ala-Glu-Gln-Lys-NH2		99.90%	Unkown
HY-113667	ASN04885796		97.55%	Unkown
HY-103018A	Gusacitinib hydrochloride	Inhibitor	/	Unkown
HY-150787	BMS-986339		/	Unkown
HY-P1043	NGR peptide		/	Unkown
HY-113761	ASN03576800	Inhibitor	99.61%	Unkown
HY-128128	ASN04421891	Modulator	/	Unkown
HY-128947	CL2 Linker		/	Unkown
HY-129360	Ala-Ala-Asn-PAB		/	Unkown
HY-129361	Fmoc-Ala-Ala-Asn-PABC-PNP		/	Unkown
HY-130933	Fmoc-Ala-Ala-Asn(Trt)-OH		/	Unkown
HY-131092	H-Asn-Arg-OH		/	Unkown
HY-136733	Ac-DNLD-CHO	Inhibitor	/	Unkown
HY-139245	MC-Ala-Ala-Asn-PAB		/	Unkown
HY-141149	Fmoc-PEG4-Ala-Ala-Asn-PAB		/	Unkown
HY-141150	Azido-PEG5-Ala-Ala-Asn-PAB		/	Unkown
HY-141151	Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB		/	Unkown
HY-144628	Fmoc-Asn-Pro-Val-PABC-PNP		/	Unkown
HY-144629	Asn-Pro-Val-PABC-MMAE TFA		/	Unkown
HY-144630	diSPhMC-Asn-Pro-Val-PABC-MMAE		/	Unkown
HY-148031	MC-Ala-Ala-Asn-PAB-PNP		/	Unkown
HY-148392	Neu5Gcα(2-6) N-Glycan-Asn		/	Unkown
HY-148393	G0 N-glycan-Asn		/	Unkown
HY-149360	P-gb-IN-1	Inhibitor	/	Unkown
HY-150579	Keap1-Nrf2-IN-13	Inhibitor	/	Unkown
HY-151146	(1R,3S)-THCCA-Asn	Inhibitor	/	Unkown
HY-156314	ASN 07115873		/	Unkown
HY-162238	OSM-S-106	Inhibitor	/	Unkown
HY-163178	Bisabosqual A		/	Unkown
HY-P1962	β-Secretase inhibitor	Inhibitor	/	Unkown
HY-P2212	Angiotensin amide		/	Unkown
HY-P2397	Fmoc-Asn(Trt)-Thr(psi(Me,Me)pro)-OH		/	Unkown
HY-P2401	Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH		/	Unkown
HY-P3615	[Asn18] Endothelin-1, human	Agonist	/	Unkown
HY-P4019	Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2		/	Unkown
HY-P4919	Mca-SEVNLDAEFK(Dnp)		/	Unkown
HY-RS01098	ASNS Human Pre-designed siRNA Set A		/	Unkown
HY-W002327S	Fmoc-Asn(Trt)-OH-13C4,15N2		/	Unkown
HY-151829	Fmoc-L-Asn(EDA-N3)-OH		/	Unkown
HY-157338	NHS-Ala-Ala-Asn-active metabolite	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ASNS	RGD	RGD:2162
Mus musculus	ASNS	MGD	MGI:1350929
Macaca mulatta	ASNS	VGNC	VGNC:80798
Felis catus	ASNS	VGNC	VGNC:69354
Canis familiaris	ASNS	VGNC	VGNC:53542

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