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Cat. No.: HY-W845197

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L-Asparagine-¹⁵N₂

(Synonyms: (-)-Asparagine-¹⁵N₂; Asn-¹⁵N₂; Asparamide-¹⁵N₂)

L-Asparagine-¹⁵N₂ ((-)-Asparagine-¹⁵N₂) is the ¹⁵N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.

For research use only. We do not sell to patients.

CAS No.: 748757-99-5
Formula: C₄H₈¹⁵N₂O₃
Molecular Weight:134.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

L-Asparagine-¹⁵N₂ Chemical Structure

CAS No.: 748757-99-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

All Endogenous Metabolite Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 748757-99-5
Unlabeled Cas 70-47-3
Molecular Weight 134.10
Formula C₄H₈¹⁵N₂O₃
SMILES

[15NH2]C(C[C@H]([15NH2])C(O)=O)=O
Synonyms

(-)-Asparagine-¹⁵N₂; Asn-¹⁵N₂; Asparamide-¹⁵N₂
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.