1. Anti-infection
  2. Bacterial
  3. Antofloxacin

Antofloxacin 

Cat. No.: HY-123319A
Handling Instructions

Antofloxacin is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin is a weak, reversible inhibitor of CYP1A2 for the treatment of infections caused by a diverse group of bacterial species.

For research use only. We do not sell to patients.

Antofloxacin Chemical Structure

Antofloxacin Chemical Structure

CAS No. : 119354-43-7

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Description

Antofloxacin is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin is a weak, reversible inhibitor of CYP1A2 for the treatment of infections caused by a diverse group of bacterial species[1][2][3].

IC50 & Target

Bacterial[1][2]

In Vivo

Antofloxacin (2.5~160 mg/kg; s.c.; 24 hours) penetration ratio ranges from 1.22 to 1.54 for the total drug concentrations and is independent of the dose levels[3]. Antofloxacin increases the plasma theophylline concentration, partly by acting as a mechanism based inhibitor of CYP1A2. Antofloxacin inhibits the formation of the three metabolites of theophylline was time-, concentration- and NADPH-dependent, which is characteristic of mechanism-based inhibition[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[3]
Dosage: 2.5~160 mg/kg (Pharmacokinetic Analysis)
Administration: S.c.; 24 hours
Result: Penetration ratio ranged from 1.22 to 1.54 for the total drug concentrations and was independent of the dose levels.
Molecular Weight

376.38

Formula

C₁₈H₂₁FN₄O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Antofloxacin
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HY-123319A
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