Antofloxacin hydrochloride
Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin hydrochloride shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin hydrochloride is a weak, reversible inhibitor of CYP1A2 for the research of infections caused by a diverse group of bacterial species.
For research use only. We do not sell to patients.
- CAS No.: 873888-67-6
- Formula: C18H22ClFN4O4
- Molecular Weight:412.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Quinolone |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (Pharmacokinetic Analysis)[3]
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Dosage:2.5~160 mg/kg
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Administration:S.c.; 24 hours
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Result:Penetration ratio ranged from 1.22 to 1.54 for the total drug concentrations and was independent of the dose levels.
Chemical Information
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CAS No. 873888-67-6
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Molecular Weight 412.84
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Formula C18H22ClFN4O4
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SMILES
OC(C1=CN2C3=C(C(N4CCN(CC4)C)=C(C(N)=C3C1=O)F)OC[C@@H]2C)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. He XJ, et al. Efficacy and Safety of Antofloxacin-Based Triple Therapy for Helicobacter pylori Eradication Failure in China [published online ahead of print, 2021 Feb 8]. Dig Dis Sci. 2021;10.1007/s10620-021-06856-z. [Content Brief]
[2]. Liu L, et al. Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans. Acta Pharmacol Sin. 2011;32(10):1285-1293. [Content Brief]
[3]. Zhou YF, et al. In Vivo Pharmacokinetic and Pharmacodynamic Profiles of Antofloxacin against Klebsiella pneumoniae in a Neutropenic Murine Lung Infection Model. Antimicrob Agents Chemother. 2017;61(5):e02691-16. Published 2017 Apr 24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antofloxacin hydrochloride Related Classifications
HY-123319 Related Classifications
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