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Cat. No.: HY-180467A

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Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium

Name: Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium
Brand: MedChemExpress
SKU: HY-180467A
Price: 870.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me (Compound G12) sodium is a disaccharide linker. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium can be efficiently recognized by the endo-glycosidase Endo-S2 and can be directedly transferred to the conserved N-glycosylation site (Asn297 position) of the antibody's Fc domain through enzymatic catalytic reactions, thereby achieving site-specific modification of the antibody. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium can be used for for the synthesis of antibody-conjugated drugs (ADCs).

For research use only. We do not sell to patients.

Formula: C₂₅H₄₀N₂NaO₁₈
Molecular Weight:679.58

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium Chemical Structure

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Description

All ADC Linkers Isoforms :

Chemical Information

Appearance Solid
Molecular Weight 679.58
Formula C₂₅H₄₀N₂NaO₁₈
SMILES

OC[C@@H](O[C@@]1([H])[C@@](N=C(O1)C)([H])[C@H]2O)[C@H]2O[C@@H]([C@@H]([C@H]([C@H]3O)O)O)O[C@@H]3CO[C@]4(O[C@@]([C@@H]([C@H](C4)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)C(O)=O.[Na]
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang W, et al. Disaccharide linker, disaccharide-small molecule drug conjugate and sugar chain fixed-point antibody-drug conjugate, and preparation method therefor and use thereof. China, WO2022174834 A. 2022-08-25.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium

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Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium

All ADC Linkers Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium Related Classifications

HY-180467A Related Classifications

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