2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. ASN04421891

ASN04421891 is a GPR17 agonist with nanomolar EC50 and high specificity. ASN04421891 promotes oligodendrocyte precursor cell maturation to mature myelinating oligodendrocytes. ASN04421891 can be used for the research of cerebral ischaemia, cardiac ischaemia, renal ischaemia, cerebral trauma, multiple sclerosis, schizophrenia, depression, alzheimer's disease, alzheimer-like dementia, parkinson's disease, huntington's chorea, amyotrophic lateral sclerosis (ALS), neuroinflammatory disorders.

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ASN04421891

ASN04421891 Chemical Structure

CAS No. : 570365-12-7

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ASN04421891 Related Antibodies

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Description

ASN04421891 is a GPR17 agonist with nanomolar EC50 and high specificity. ASN04421891 promotes oligodendrocyte precursor cell maturation to mature myelinating oligodendrocytes. ASN04421891 can be used for the research of cerebral ischaemia, cardiac ischaemia, renal ischaemia, cerebral trauma, multiple sclerosis, schizophrenia, depression, alzheimer's disease, alzheimer-like dementia, parkinson's disease, huntington's chorea, amyotrophic lateral sclerosis (ALS), neuroinflammatory disorders[1].

In Vitro

ASN04421891 exhibits an EC50 of 3.67 nM as an agonist in GPR17-transfected human 1321N1 cells, with a potency reaching 142.8% of that of the reference agonist LTC4[1].
ASN04421891 (10 nM; 48 h) promotes the differentiation of primary rat oligodendrocyte precursor cells into mature, myelin basic protein-positive oligodendrocytes, with an activity of 140%-170% of that in the vehicle control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ASN04421891 Related Antibodies
Molecular Weight

524.61

Formula

C30H32N6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C=C(OC)C=C2)C=C1C(C3=NN=NN3CCOC)N(CCC4=CC=CC=C4)CC5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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ASN04421891 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASN04421891570365-12-7ASN 04421891ASN-04421891Transmembrane Glycoproteinoligodendrocyte precursor cellcerebral ischaemiaschizophreniarenal ischaemiacardiac ischaemiaGPR17mature myelinating oligodendrocytescerebral traumamultiple sclerosisalzheimer's diseaseInhibitorinhibitorinhibit

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ASN04421891
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HY-128128
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