ASN04421891
Based on 1 Customer Validation
ASN04421891 is a GPR17 agonist with nanomolar EC50 and high specificity. ASN04421891 promotes oligodendrocyte precursor cell maturation to mature myelinating oligodendrocytes. ASN04421891 can be used for the research of cerebral ischaemia, cardiac ischaemia, renal ischaemia, cerebral trauma, multiple sclerosis, schizophrenia, depression, alzheimer's disease, alzheimer-like dementia, parkinson's disease, huntington's chorea, amyotrophic lateral sclerosis (ALS), neuroinflammatory disorders.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 570365-12-7
- Formula: C30H32N6O3
- Molecular Weight:524.61
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
ASN04421891 exhibits an EC50 of 3.67 nM as an agonist in GPR17-transfected human 1321N1 cells, with a potency reaching 142.8% of that of the reference agonist LTC4[1].
ASN04421891 (10 nM; 48 h) promotes the differentiation of primary rat oligodendrocyte precursor cells into mature, myelin basic protein-positive oligodendrocytes, with an activity of 140%-170% of that in the vehicle control group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 570365-12-7
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Appearance Solid
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Molecular Weight 524.61
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Formula C30H32N6O3
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Color White to off-white
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SMILES
O=C1NC2=C(C=C(OC)C=C2)C=C1C(C3=NN=NN3CCOC)N(CCC4=CC=CC=C4)CC5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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