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Z-Ala-Ala-Asn-AMC (Synonyms: Cbz-Ala-Ala-Asn-AMC)

Cat. No.: HY-136626
Handling Instructions

Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC.

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Z-Ala-Ala-Asn-AMC Chemical Structure

Z-Ala-Ala-Asn-AMC Chemical Structure

CAS No. : 149697-16-5

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Description

Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1].

In Vitro

The first legumain fluorogenic substrate Cbz-Ala-Ala-Asn-AMC based on the P3-P2-P1 sequence Ala-Ala-Asn. The synthetic substrate Cbz-Ala-Ala-Asn-AMC is effectively cleaved by S. mansoni legumain and human legumain with Kms of 90 and 80 uM respectively[2][3].

Molecular Weight

566.56

Formula

C₂₈H₃₀N₄O₉

CAS No.

149697-16-5

SMILES

O=C(O)C[[email protected]@H](C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O)NC([[email protected]](C)NC([[email protected]](C)NC(OCC3=CC=CC=C3)=O)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Z-Ala-Ala-Asn-AMCCbz-Ala-Ala-Asn-AMCOtherslegumainsubstrateInhibitorinhibitorinhibit

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