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RR-11a analog 

Cat. No.: HY-112205A Purity: 99.16%
Handling Instructions

RR-11a analog is a potent and selective inhibitors of asparaginyl endopeptidases (AE) (Legumain), with IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively.

For research use only. We do not sell to patients.

RR-11a analog Chemical Structure

RR-11a analog Chemical Structure

CAS No. : 685543-66-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of RR-11a analog:

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  • Biological Activity

  • Technical Information

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  • References

Description

RR-11a analog is a potent and selective inhibitors of asparaginyl endopeptidases (AE) (Legumain), with IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively[1].

IC50 & Target

IC50: 4.5 nM (AE1 in Trichomonas Vaginalis), 4.5 nM (AE in Ixodes ricinus), 31 nM (AE in Schistosoma mansoni)[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (254.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0346 mL 10.1731 mL 20.3463 mL
5 mM 0.4069 mL 2.0346 mL 4.0693 mL
10 mM 0.2035 mL 1.0173 mL 2.0346 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.23 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

491.49

Formula

C₂₂H₂₉N₅O₈

CAS No.

685543-66-2

SMILES

O=C(N[[email protected]@H](C)C(N[[email protected]@H](C)C(NN(CC(N)=O)C(/C=C/C(OCC)=O)=O)=O)=O)OCC1=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.16%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
RR-11a analog
Cat. No.:
HY-112205A
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RR-11a analog

Cat. No.: HY-112205A