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RR-11a 

Cat. No.: HY-112205
Handling Instructions

RR-11a is a synthetic enzyme inhibitor of Legumain.

For research use only. We do not sell to patients.

RR-11a Chemical Structure

RR-11a Chemical Structure

CAS No. : 1361390-56-8

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Description

RR-11a is a synthetic enzyme inhibitor of Legumain.

IC50 & Target

Legumain[1]

In Vitro

Legumain-targeted RR-11a-coupled nanoparticles reveal high ligand-receptor affinity, enhance solid-tumor penetration and uptake by tumor cells[1].

In Vivo

Treatment of tumor-bearing mice with RR-11a-coupled NPs encapsulating doxorubicin results in improved tumor selectivity and drug sensitivity, leading to complete inhibition of tumor growth[1].

Molecular Weight

560.51

Formula

C₂₄H₂₈N₆O₁₀

CAS No.

1361390-56-8

SMILES

O=C(N[[email protected]@H](C)C(N[[email protected]@H](C)C(NN(CC(N)=O)C(/C=C/C(ON1C(CCC1=O)=O)=O)=O)=O)=O)OCC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Mice[1]

Mice bearing 4T1 orthothopic tumors of approximately 500 mm3 are injected once intravenously with RR-11a+ or RR-11a-nanoparticles labeled with rhodamine B. Alternatively, mice are injected intravenously 3 times at 48-hour intervals with RDZ-218, NP-DOX, free DOX, or saline. Twenty-four hours after the final treatment, animals are sacrificed and spleen, kidney, lungs, liver, heart and tumor are collected, frozen in OCT compound, immediately sectioned and imaged by fluorescence microscopy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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RR-11a
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