1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. SHA 68

SHA 68 

Cat. No.: HY-108625 Purity: 98.05%
Handling Instructions

SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.

For research use only. We do not sell to patients.

SHA 68 Chemical Structure

SHA 68 Chemical Structure

CAS No. : 847553-89-3

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 595 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia[1][2].

IC50 & Target

IC50: 22 nM (Asn107) and 23.8 nM (Ile107)[1]

In Vivo

SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing[1].
SHA 68 (i.v.; 1 mg/kg) has a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg[1].
SHA 68 (i.p.; 2.5 mg/kg) has a T1/2 of 0.43 hours, a CL of 4.56 mL/min/kg[1].

Animal Model: Male C57BL/6 mice age 8-12 weeks[1]
Dosage: 5 and 50 mg/kg
Administration: i.p.
Result: Reduced NPS-induced horizontal activity and vertical rearing and climbing.
Animal Model: Male C57BL/6 mice age 8-12 weeks[1]
Dosage: 1 mg/kg (Pharmacokinetic Analysis)
Administration: i.p.
Result: Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.
Molecular Weight

445.49

Formula

C₂₆H₂₄FN₃O₃

CAS No.

847553-89-3

SMILES

O=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCC5=CC=C(F)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (561.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2447 mL 11.2236 mL 22.4472 mL
5 mM 0.4489 mL 2.2447 mL 4.4894 mL
10 mM 0.2245 mL 1.1224 mL 2.2447 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SHA 68SHA68SHA-68Neuropeptide Y ReceptorNPY receptornon-peptideneuropeptideSreceptorNPSRAsn107NPSR Ile107BBBneuralgiaInhibitorinhibitorinhibit

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SHA 68
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HY-108625
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