Fmoc-Ala-Glu-Asn-Lys-NH2
Based on 3 publication(s) in Google Scholar
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 220701-06-4
- Formula: C33H43N7O9
- Molecular Weight:681.74
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-N0615
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HY-P1466
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HY-P1363A
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HY-P1363B
β-Amyloid (1-42), human, HFIP-treated
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HY-P1880
β-Amyloid (12-20)
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HY-N0045
Ginsenoside Rg1
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HY-19370
FPS-ZM1
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HY-P1362
β-Amyloid (42-1), human
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HY-P2268
RAGE antagonist peptide
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HY-N0009
Geniposide
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HY-N0249
Saikosaponin C
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HY-N0602
Ginsenoside Rg2
Publications Citing Use of MedChemExpress (MCE) Fmoc-Ala-Glu-Asn-Lys-NH2
More
Biological Activity
Chemical Information
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CAS No. 220701-06-4
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Appearance Solid
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Molecular Weight 681.74
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Formula C33H43N7O9
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Color White to off-white
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Sequence Shortening
{Fmoc}-AENK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Aging
2025 Mar;5(3):486-503. PMID: 39779912 -
Mater Today Bio
Intranasal delivery of AEP inhibitor-loaded neuron-targeted liposome ameliorates radiation-induced brain injury. [Abstract]2025 Feb 11:31:101568. PMID: 40026629 -
Adv Radiat Oncol
Targeting Active Microglia Alleviates Distal Edge of Proton Radiation-induced Neural Damage. [Abstract]2025 Mar 18;10(5):101764. PMID: 40291513
Solvent & Solubility
DMSO : 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 10 mg/mL (14.67 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9. [Content Brief]
[2]. Chen G, et al. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Sci Adv. 2021 Apr 16;7(16):eabe4499. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.4668 mL | 7.3342 mL | 14.6683 mL | 36.6709 mL |
| 5 mM | 0.2934 mL | 1.4668 mL | 2.9337 mL | 7.3342 mL | |
| 10 mM | 0.1467 mL | 0.7334 mL | 1.4668 mL | 3.6671 mL | |
| DMSO | 15 mM | 0.0978 mL | 0.4889 mL | 0.9779 mL | 2.4447 mL |
| 20 mM | 0.0733 mL | 0.3667 mL | 0.7334 mL | 1.8335 mL | |
| 25 mM | 0.0587 mL | 0.2934 mL | 0.5867 mL | 1.4668 mL | |
| 30 mM | 0.0489 mL | 0.2445 mL | 0.4889 mL | 1.2224 mL | |
| 40 mM | 0.0367 mL | 0.1834 mL | 0.3667 mL | 0.9168 mL | |
| 50 mM | 0.0293 mL | 0.1467 mL | 0.2934 mL | 0.7334 mL | |
| 60 mM | 0.0244 mL | 0.1222 mL | 0.2445 mL | 0.6112 mL | |
| 80 mM | 0.0183 mL | 0.0917 mL | 0.1834 mL | 0.4584 mL | |
| 100 mM | 0.0147 mL | 0.0733 mL | 0.1467 mL | 0.3667 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fmoc-Ala-Glu-Asn-Lys-NH2 Related Classifications
HY-114174 Related Classifications
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