1. Neuronal Signaling
  2. Amyloid-β
  3. Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fmoc-Ala-Glu-Asn-Lys-NH2 Chemical Structure

Fmoc-Ala-Glu-Asn-Lys-NH2 Chemical Structure

CAS No. : 220701-06-4

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5 mg USD 135 In-stock
10 mg USD 235 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

In Vitro

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

681.74

Formula

C33H43N7O9

CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

{Fmoc}-AENK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 10 mg/mL (14.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4668 mL 7.3342 mL 14.6683 mL
5 mM 0.2934 mL 1.4668 mL 2.9337 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.62%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.4668 mL 7.3342 mL 14.6683 mL 36.6709 mL
5 mM 0.2934 mL 1.4668 mL 2.9337 mL 7.3342 mL
10 mM 0.1467 mL 0.7334 mL 1.4668 mL 3.6671 mL
DMSO 15 mM 0.0978 mL 0.4889 mL 0.9779 mL 2.4447 mL
20 mM 0.0733 mL 0.3667 mL 0.7334 mL 1.8335 mL
25 mM 0.0587 mL 0.2934 mL 0.5867 mL 1.4668 mL
30 mM 0.0489 mL 0.2445 mL 0.4889 mL 1.2224 mL
40 mM 0.0367 mL 0.1834 mL 0.3667 mL 0.9168 mL
50 mM 0.0293 mL 0.1467 mL 0.2934 mL 0.7334 mL
60 mM 0.0244 mL 0.1222 mL 0.2445 mL 0.6112 mL
80 mM 0.0183 mL 0.0917 mL 0.1834 mL 0.4584 mL
100 mM 0.0147 mL 0.0733 mL 0.1467 mL 0.3667 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fmoc-Ala-Glu-Asn-Lys-NH2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Fmoc-Ala-Glu-Asn-Lys-NH2
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