1. Neuronal Signaling
  2. Amyloid-β
  3. Fmoc-Ala-Glu-Asn-Lys-NH2

Fmoc-Ala-Glu-Asn-Lys-NH2 

Cat. No.: HY-114174 Purity: 98.04%
Handling Instructions

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fmoc-Ala-Glu-Asn-Lys-NH2 Chemical Structure

Fmoc-Ala-Glu-Asn-Lys-NH2 Chemical Structure

CAS No. : 220701-06-4

Size Price Stock Quantity
5 mg USD 135 In-stock
Estimated Time of Arrival: December 31
10 mg USD 235 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

In Vitro

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

681.74

Formula

C₃₃H₄₃N₇O₉

CAS No.
Sequence Shortening

{Fmoc}-AENK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light, stored under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4668 mL 7.3342 mL 14.6683 mL
5 mM 0.2934 mL 1.4668 mL 2.9337 mL
10 mM 0.1467 mL 0.7334 mL 1.4668 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.04%

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Keywords:

Fmoc-Ala-Glu-Asn-Lys-NH2Amyloid-ββ-amyloid peptideAbetaAPPpeptideAEPproteinaseproteolyticprocessingInhibitorinhibitorinhibit

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Product Name:
Fmoc-Ala-Glu-Asn-Lys-NH2
Cat. No.:
HY-114174
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