H-Asn-Pro-Glu-Tyr(PO3H2)-OH
H-Asn-Pro-Glu-Tyr(PO3H2)-OH is a phosphorylated peptide derivative of the tetramine motif Asn-Pro-Glu-Tyr (NPEY), and is a substrate binding domain common to the insulin-like growth factor-I receptor (IGF-IR) and the insulin receptor (IR).
For research use only. We do not sell to patients.
- CAS No.: 290810-63-8
- Formula: C23H32N5O12P
- Molecular Weight:601.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Chemical Information
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CAS No. 290810-63-8
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Molecular Weight 601.50
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Formula C23H32N5O12P
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Sequence
Asn-Pro-Glu-Tyr(PO3H2)
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Sequence Shortening
NPE-Tyr(PO2H2)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)