2. Membrane Transporter/Ion Channel
  3. ASCT
  4. cis-3-Hydroxyproline

cis-L-3-Hydroxyproline is an Alanine-Serine-Cysteine transporter 2 (ASCT2, SLC1A5) substrate that can induces inwardly-directed anion current, and forms key interactions with ASCT2 binding site residues including Asn471.cis-L-3-Hydroxyproline can be used for the research of melanoma.

For research use only. We do not sell to patients.

cis-3-Hydroxyproline

cis-3-Hydroxyproline Chemical Structure

CAS No. : 567-35-1

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cis-3-Hydroxyproline Related Antibodies

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Description

cis-L-3-Hydroxyproline is an Alanine-Serine-Cysteine transporter 2 (ASCT2, SLC1A5) substrate that can induces inwardly-directed anion current, and forms key interactions with ASCT2 binding site residues including Asn471.cis-L-3-Hydroxyproline can be used for the research of melanoma[1].

In Vitro

cis-L-3-Hydroxyproline (0-5 mM) activates ASCT2 in ASCT2-expressing HEK293 cells with a Km of 0.019 ± 0.01 mM, inducing a maximum current 1.39-fold higher than that of 1 mM alanine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cis-3-Hydroxyproline Related Antibodies
Molecular Weight

131.13

Formula

C5H9NO3
CAS No.
Appearance

Solid

SMILES

C(O)(=O)[C@@H]1[C@H](O)CCN1
Structure Classification
Initial Source

Streptomyces sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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cis-3-Hydroxyproline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-3-Hydroxyproline567-35-1ASCTAlanine Serine Cysteine TransportersASCT2alanineSLC1A5Asn471HEK293 cellsmelanomaAlanine-Serine-Cysteine transporter 2Inhibitorinhibitorinhibit

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