Exatecan-mpGly-Asn-Asn-(βAla)

Cat. No.: HY-176977 Purity: 96.25%: Data Sheet
COA

SDS
Handling Instructions
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Exatecan-mpGly-Asn-Asn-(βAla) (Compound 10b) is a conjugate of Exatecan (HY-13631) and a linker. Exatecan-mpGly-Asn-Asn-(βAla) can be used to synthesize ADCs, such as α-HER2_mpGlyAsnAsn(β-Ala)_Exatecan. Exatecan-mpGly-Asn-Asn-(βAla) can also be used in tumor research.

For research use only. We do not sell to patients.

Exatecan-mpGly-Asn-Asn-(βAla) Chemical Structure

CAS No. : 3076725-07-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

942.90

Formula

C₄₄H₄₇FN₁₀O₁₃

CAS No.

3076725-07-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=CC1=O)N1CCC(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(NCCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (106.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0606 mL	5.3028 mL	10.6056 mL
5 mM	0.2121 mL	1.0606 mL	2.1211 mL
10 mM	0.1061 mL	0.5303 mL	1.0606 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.25%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (264 KB) HNMR (541 KB) RP-HPLC (226 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Ojo VT, et al. Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self-Immolative Spacers Demonstrate Potent Antitumor Activity. J Med Chem. 2025 Dec 11;68(23):25505-25522. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0606 mL	5.3028 mL	10.6056 mL	26.5139 mL
	5 mM	0.2121 mL	1.0606 mL	2.1211 mL	5.3028 mL
	10 mM	0.1061 mL	0.5303 mL	1.0606 mL	2.6514 mL
	15 mM	0.0707 mL	0.3535 mL	0.7070 mL	1.7676 mL
	20 mM	0.0530 mL	0.2651 mL	0.5303 mL	1.3257 mL
	25 mM	0.0424 mL	0.2121 mL	0.4242 mL	1.0606 mL
	30 mM	0.0354 mL	0.1768 mL	0.3535 mL	0.8838 mL
	40 mM	0.0265 mL	0.1326 mL	0.2651 mL	0.6628 mL
	50 mM	0.0212 mL	0.1061 mL	0.2121 mL	0.5303 mL
	60 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.4419 mL
	80 mM	0.0133 mL	0.0663 mL	0.1326 mL	0.3314 mL
	100 mM	0.0106 mL	0.0530 mL	0.1061 mL	0.2651 mL