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Sacituzumab govitecan (solution)

(Synonyms: IMMU-132 (solution))
12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. The antibody portion is Sacituzumab (HY-P99045), and the drug-linker conjugate for ADC is CL2A-SN-38 (HY-128946). Sacituzumab govitecan shows anticancer activity.

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  • Pureté : 99.19%
  • CAS No.: 1491917-83-9
  • Masse moléculaire:157364 (average)
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  • Sacituzumab govitecan (solution) Chemical Structure
    Sacituzumab govitecan (solution) Chemical Structure
  • Experimental Validation Results for Sacituzumab govitecan (solution)
  • Experimental Validation Results for Sacituzumab govitecan (solution)
  • Experimental Validation Results for Sacituzumab govitecan (solution)
  • Experimental Validation Results for Sacituzumab govitecan (solution)
  • Experimental Validation Results for Sacituzumab govitecan (solution)
  • Experimental Validation Results for Sacituzumab govitecan (solution)
  • Experimental Validation Results for Sacituzumab govitecan (solution)
CAS No.: 1491917-83-9
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  • Sacituzumab govitecan (solution) Chemical Structure
    Sacituzumab govitecan (solution) Chemical Structure
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    Sacituzumab govitecan (solution) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Apr 26;16(1):346. [Abstract]

    Customer Validation
     Cell morphology was observed under a microscope (SG, 10 nM, 24 h) (Scale bar: 100 µm).

  • 1/16

    Sacituzumab govitecan (solution) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Apr 26;16(1):346. [Abstract]

    Customer Validation
     Cell viability was assessed after 24 h of treatment with 10 nM SG at various concentrations using the CCK-8 assay.

  • 1/16

    Sacituzumab govitecan (solution) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Apr 26;16(1):346. [Abstract]

    Customer Validation
     Representative fluorescence images and quantification of tail moment in parental and resistant cells (SG, 10 nM, 24 h).

  • 1/16

    Sacituzumab govitecan (solution) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Apr 26;16(1):346. [Abstract]

    Customer Validation
     The heatmap displays gene expression in the resistant group compared to the parental group in MCF-7 cells (SG, 10 nM, 24 h). The colors of the heatmap reflect log2 expression levels of genes.

  • 1/16

    Sacituzumab govitecan (solution) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Apr 26;16(1):346. [Abstract]

    Customer Validation
     After knockdown of BCL2A1, WFDC3, PI3, CLDN5, and MMP1 separately, the viability of MCF-7-Pa and T47D-Pa was tested at different concentrations of SG (0-200 nM) using CCK-8 assays.

  • 1/16

    Sacituzumab govitecan (solution) purchased from MedChemExpress. Usage Cited in: Anal Chem. 2025 Oct 28;97(42):23598-23608. [Abstract]

    Customer Validation
     Time course of tumor volume of MDA-MB-468 tumor-bearing mice treated with PBS, SG (10 mg/kg, tail vein injection), and Dato-DXd (10 mg/kg, tail vein injection).

  • 1/16

    Sacituzumab govitecan (solution) purchased from MedChemExpress. Usage Cited in: Anal Chem. 2025 Oct 28;97(42):23598-23608. [Abstract]

    Customer Validation
     MicroPET imaging of MDA-MB-468 tumor-bearing mice at different time postinjection of [68Ga]Ga-NOTA-PEG2-WP8 during PBS, SG (10 mg/kg, tail vein injection) and Dato-DXd (10 mg/kg, tail vein injection) treatment for 0, 9, and 18 days, respectively. White dotted line circles indicate the tumor locations.

  • Sacituzumab govitecan (solution)