HC-7366
Based on 1 Customer Validation
HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC50 being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC50 being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia.
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 2803470-63-3
- Formula: C20H15ClF2N6O4S
- Molecular Weight:508.89
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
HC-7366 (0.1 nM-0.1 μM, 72 h) significantly inhibited the proliferation of MOLM-16 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HT1080 and MOLM-16 xenograft models established in female BALB/c nude mice[1]
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Dosage:0.3, 1 and 3 mg/kg
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Administration:Oral administration (p.o.), twice daily for 17 or 31 days
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Result:Demonstrated potent tumor growth inhibition.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2803470-63-3
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Appearance Solid
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Molecular Weight 508.89
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Formula C20H15ClF2N6O4S
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Color White to off-white
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SMILES
O=C(C1=C2C=NC(C3=C(C=CC(NS(=O)(C4=CC(Cl)=CN=C4OC)=O)=C3F)F)=CN2C=N1)NC
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Synonyms
GCN2 modulator-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 31.25 mg/mL (61.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9651 mL | 9.8253 mL | 19.6506 mL | 49.1265 mL |
| 5 mM | 0.3930 mL | 1.9651 mL | 3.9301 mL | 9.8253 mL | |
| 10 mM | 0.1965 mL | 0.9825 mL | 1.9651 mL | 4.9127 mL | |
| 15 mM | 0.1310 mL | 0.6550 mL | 1.3100 mL | 3.2751 mL | |
| 20 mM | 0.0983 mL | 0.4913 mL | 0.9825 mL | 2.4563 mL | |
| 25 mM | 0.0786 mL | 0.3930 mL | 0.7860 mL | 1.9651 mL | |
| 30 mM | 0.0655 mL | 0.3275 mL | 0.6550 mL | 1.6376 mL | |
| 40 mM | 0.0491 mL | 0.2456 mL | 0.4913 mL | 1.2282 mL | |
| 50 mM | 0.0393 mL | 0.1965 mL | 0.3930 mL | 0.9825 mL | |
| 60 mM | 0.0328 mL | 0.1638 mL | 0.3275 mL | 0.8188 mL |
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