2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. HC-7366

HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC50 being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC50 being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia.

For research use only. We do not sell to patients.

HC-7366

HC-7366 Chemical Structure

CAS No. : 2803470-63-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

HC-7366 Related Antibodies

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Description

HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC50 being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC50 being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia[1].

In Vitro

HC-7366 (0.1 nM-0.1 μM, 72 h) significantly inhibited the proliferation of MOLM-16 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HC-7366 Related Antibodies
Parmacokinetics
Species Dose Route CLunbound Vss T1/2 Cmax AUC F
Mice[1] 1 mg/kg i.v. 0.14 mL/min/kg 0.12 L/kg 10 h 26.135 μM / /
Rat[1] 3 mg/kg p.o. / / / / 63000000 μg·h/mL 66 %
In Vivo

HC-7366 (0.3-3 mg/kg, p.o., twice daily for 17 or 31 days) demonstrates significant anti-tumor effects in the HT1080 and MOLM-16 mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HT1080 and MOLM-16 xenograft models established in female BALB/c nude mice[1]
Dosage: 0.3, 1 and 3 mg/kg
Administration: Oral administration (p.o.), twice daily for 17 or 31 days
Result: Demonstrated potent tumor growth inhibition.
Clinical Trial
Molecular Weight

508.89

Formula

C20H15ClF2N6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2C=NC(C3=C(C=CC(NS(=O)(C4=CC(Cl)=CN=C4OC)=O)=C3F)F)=CN2C=N1)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (61.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9651 mL 9.8253 mL 19.6506 mL
5 mM 0.3930 mL 1.9651 mL 3.9301 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

SDS (252 KB)

COA (250 KB) HNMR (281 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9651 mL 9.8253 mL 19.6506 mL 49.1265 mL
5 mM 0.3930 mL 1.9651 mL 3.9301 mL 9.8253 mL
10 mM 0.1965 mL 0.9825 mL 1.9651 mL 4.9127 mL
15 mM 0.1310 mL 0.6550 mL 1.3100 mL 3.2751 mL
20 mM 0.0983 mL 0.4913 mL 0.9825 mL 2.4563 mL
25 mM 0.0786 mL 0.3930 mL 0.7860 mL 1.9651 mL
30 mM 0.0655 mL 0.3275 mL 0.6550 mL 1.6376 mL
40 mM 0.0491 mL 0.2456 mL 0.4913 mL 1.2282 mL
50 mM 0.0393 mL 0.1965 mL 0.3930 mL 0.9825 mL
60 mM 0.0328 mL 0.1638 mL 0.3275 mL 0.8188 mL
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HC-7366 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HC-73662803470-63-3GCN2 modulator-1HC7366HC 7366Eukaryotic Initiation Factor (eIF)general control nonderepressible kinase 2 (GCN2)Inhibitorinhibitorinhibit

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