2803470-63-3
Chemical Structure
HC-7366
Synonym(s): GCN2 modulator-1
- CAS No.: 2803470-63-3
- Formula:C20H15ClF2N6O4S
- Molecular Weight:508.89
InChIKey: KIGXQRBUVDDSPP-UHFFFAOYSA-N
SMILES: O=C(C1=C2C=NC(C3=C(C=CC(NS(=O)(C4=CC(Cl)=CN=C4OC)=O)=C3F)F)=CN2C=N1)NC
Biological Activity: HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC50 being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC50 being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia[1].
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HC-7366 | 99.58% | HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC50 being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC50 being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia. | ||||||||||||||||||||
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Keywords
