2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K/mTOR Inhibitor-2

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR. Antitumor activity.

For research use only. We do not sell to patients.

PI3K/mTOR Inhibitor-2 Chemical Structure

PI3K/mTOR Inhibitor-2 Chemical Structure

CAS No. : 1848242-58-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 316 In-stock
Solution
10 mM * 1 mL in DMSO USD 316 In-stock
Solid
1 mg USD 110 In-stock
5 mg USD 300 In-stock
10 mg USD 490 In-stock
50 mg USD 1400 In-stock
100 mg USD 2000 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

PI3K/mTOR Inhibitor-2 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PI3K/mTOR Inhibitor-2

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

  • Biological Activity

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Description

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].

IC50 & Target[1]

PI3Kα

3.4 nM (IC50)

PI3Kβ

34 nM (IC50)

PI3Kδ

16 nM (IC50)

PI3Kγ

1 nM (IC50)

mTOR

4.7 nM (IC50)

In Vitro

PI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC50s of 11.6 and 89.2 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/mTOR Inhibitor-2 Related Antibodies
Molecular Weight

478.86

Formula

C20H13ClF2N4O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=CC(F)=C(S(=O)(NC2=CC(C(C=C3)=CN4C3=NC=C(Cl)C4=O)=CN=C2OC)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (17.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0883 mL 10.4415 mL 20.8829 mL
5 mM 0.4177 mL 2.0883 mL 4.1766 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0883 mL 10.4415 mL 20.8829 mL 52.2073 mL
5 mM 0.4177 mL 2.0883 mL 4.1766 mL 10.4415 mL
10 mM 0.2088 mL 1.0441 mL 2.0883 mL 5.2207 mL
15 mM 0.1392 mL 0.6961 mL 1.3922 mL 3.4805 mL
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PI3K/mTOR Inhibitor-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-21848242-58-9PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinInhibitorinhibitorinhibit

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