1. PI3K/Akt/mTOR
  2. PI3K
    mTOR

PI3K/mTOR Inhibitor-2 

Cat. No.: HY-111508
Handling Instructions

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR. Antitumor activity.

For research use only. We do not sell to patients.

PI3K/mTOR Inhibitor-2 Chemical Structure

PI3K/mTOR Inhibitor-2 Chemical Structure

CAS No. : 1848242-58-9

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  • Biological Activity

  • Technical Information

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  • References

Description

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].

IC50 & Target[1]

PI3Kα

3.4 nM (IC50)

PI3Kβ

34 nM (IC50)

PI3Kδ

16 nM (IC50)

PI3Kγ

1 nM (IC50)

mTOR

4.7 nM (IC50)

In Vitro

PI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC50s of 11.6 and 89.2 nM, respectively[1].

References
Molecular Weight

478.86

Formula

C₂₀H₁₃ClF₂N₄O₄S

CAS No.

1848242-58-9

SMILES

FC1=CC(F)=C(S(=O)(NC2=CC(C(C=C3)=CN4C3=NC=C(Cl)C4=O)=CN=C2OC)=O)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PI3K/mTOR Inhibitor-2
Cat. No.:
HY-111508
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PI3K/mTOR Inhibitor-2

Cat. No.: HY-111508