PI3K/mTOR Inhibitor-13
PI3K/mTOR Inhibitor-13 is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF).
For research use only. We do not sell to patients.
- CAS No.: 1621718-37-3
- Formula: C20H13F2N5O3S
- Molecular Weight:441.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PI3K/mTOR Inhibitor-13 (Compound A) (0-2 µM; 48 h) inhibits the proliferation of HFL1 cells with dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HFL1 cells.
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Concentration:0, 0.03125, 0.0125, 0.025, 0.05, 0.0625, 0.1, 0.125, 0.2, 0.25, 0.4, 0.5, 1 and 2 µM.
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Incubation Time:48 h.
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Result:Showed inhibitory for HFL1 cells.
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Cell Line:HFL1 cells.
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Concentration:200 nM.
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Incubation Time:48 h.
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Result:Increased the expression of α-SMA/Tubulin.
| Species | Administration manner | Dose (mg/kg) | T1/2 (h) | AUClast (ng•h/mL) | Cl/F (L/h/kg) | Vss (L/kg) | F (%) |
| Rat | Intravenous injection | 2 | 2.77 | 7069 | 0.29 | 0.85 | 94.75 |
| Mice | Intravenous injection | 1 | 5.45 | 57059 | 0.02 | 0.13 | 79.3 |
| Dog | Intravenous injection | 1 | 0.67 | 3672 | 0.27 | 0.23 | 108.5 |
| Monkey | Intravenous injection | 1 | 9.70 | 5978 | 0.16 | 0.92 | 59.8 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1621718-37-3
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Molecular Weight 441.41
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Formula C20H13F2N5O3S
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SMILES
N#CC1=C2C=C(C3=CC(NS(=O)(C4=CC=C(C=C4F)F)=O)=C(OC)N=C3)C=CN2N=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K/mTOR Inhibitor-13 Related Classifications
HY-153120 Related Classifications
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