2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K/mTOR Inhibitor-13

PI3K/mTOR Inhibitor-13 is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF).

For research use only. We do not sell to patients.

PI3K/mTOR Inhibitor-13 Chemical Structure

PI3K/mTOR Inhibitor-13 Chemical Structure

CAS No. : 1621718-37-3

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PI3K/mTOR Inhibitor-13 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

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Description

PI3K/mTOR Inhibitor-13 is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF)[1][2].

In Vitro

PI3K/mTOR Inhibitor-13 (Compound A) (0-2 µM; 48 h) inhibits the proliferation of HFL1 cells with dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/mTOR Inhibitor-13 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HFL1 cells.
Concentration: 0, 0.03125, 0.0125, 0.025, 0.05, 0.0625, 0.1, 0.125, 0.2, 0.25, 0.4, 0.5, 1 and 2 µM.
Incubation Time: 48 h.
Result: Showed inhibitory for HFL1 cells.

Western Blot Analysis[1]

Cell Line: HFL1 cells.
Concentration: 200 nM.
Incubation Time: 48 h.
Result: Increased the expression of α-SMA/Tubulin.
In Vivo

Pharmacokinetic (PK) parameters of PI3K/mTOR Inhibitor-13[2]

Species Administration manner Dose (mg/kg) T1/2 (h) AUClast (ng•h/mL) Cl/F (L/h/kg) Vss (L/kg) F (%)
Rat Intravenous injection 2 2.77 7069 0.29 0.85 94.75
Mice Intravenous injection 1 5.45 57059 0.02 0.13 79.3
Dog Intravenous injection 1 0.67 3672 0.27 0.23 108.5
Monkey Intravenous injection 1 9.70 5978 0.16 0.92 59.8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

441.41

Formula

C20H13F2N5O3S
CAS No.
SMILES

N#CC1=C2C=C(C3=CC(NS(=O)(C4=CC=C(C=C4F)F)=O)=C(OC)N=C3)C=CN2N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K/mTOR Inhibitor-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-131621718-37-3PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinHFL1 cellsRatMiceDogMonkeyInhibitorinhibitorinhibit

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