1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. CL2 Linker

CL2 Linker 

Cat. No.: HY-128947
Handling Instructions

CL2 Linker is an ADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).

For research use only. We do not sell to patients.

CL2 Linker Chemical Structure

CL2 Linker Chemical Structure

CAS No. : 2270986-66-6

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Description

CL2 Linker is an ADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].

IC50 & Target

Alkyl/ether

 

Molecular Weight

1426.61

Formula

C₆₈H₁₀₃N₁₁O₂₂

CAS No.

2270986-66-6

SMILES

OCC(COC(N(C)CCN(C)C(OCC(C=C1)=CC=C1NC([[email protected]](CCCCNC(OC(C)(C)C)=O)NC([[email protected]@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN2C=C(CNC(CCCCCN3C(C=CC3=O)=O)=O)N=N2)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CL2 Linker
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