2270986-66-6

CL2 Linker Chemical Structure
2270986-66-6

Chemical Structure

CL2 Linker

  • No. CAS: 2270986-66-6
  • Formula:C68H103N11O22
  • Molecular Weight:1426.61

IUPAC Name: 4-((29S,32S)-29-benzyl-32-(4-((tert-butoxycarbonyl)amino)butyl)-1-(4-((6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)methyl)-1H-1,2,3-triazol-1-yl)-27,30-dioxo-3,6,9,12,15,18,21,24-octaoxa-28,31-diazatritriacontan-33-amido)benzyl (3-hydroxy-2-oxoprop

InChIKey: BGFZCTPREVDQQQ-YQOHNZFASA-N

SMILES: OCC(COC(N(C)CCN(C)C(OCC(C=C1)=CC=C1NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN2C=C(CNC(CCCCCN3C(C=CC3=O)=O)=O)N=N2)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O

Biological Activity: CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].

Referencia número Nombre del producto Pureza Descripciòn Pricing
HY-128947 		CL2 Linker CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).
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