ASN-1377642
ASN-1377642 is a NK1 receptor antagonist with a Ki value of 251 nM. ASN-1377642 shows antitumor action in breast cancer cells with NK1R-Tr high expression.
For research use only. We do not sell to patients.
- CAS No.: 337505-63-2
- Formula: C21H16ClN5OS
- Molecular Weight:421.90
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NK1R 251 nM (Ki) |
Chemical Information
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CAS No. 337505-63-2
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Appearance Solid
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Molecular Weight 421.90
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Formula C21H16ClN5OS
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Color White to off-white
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SMILES
O=C(NC1=CC=CC(Cl)=C1)CSC2=NN=C(C3=CC=NC=C3)N2C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhou Y, et al. Roles of full-length and truncated neurokinin-1 receptors on tumor progression and distant metastasis in human breast cancer. Breast Cancer Res Treat. 2013 Jul;140(1):49-61. [Content Brief]
[2]. Evers A, et al. Ligand-supported homology modeling of g-protein-coupled receptor sites: models sufficient for successful virtual screening. Angew Chem Int Ed Engl. 2004 Jan;43(2):248-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ASN-1377642 Related Classifications
HY-131463 Related Classifications
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