337505-63-2
337505-63-2
Chemical Structure
ASN-1377642
- CAS No.: 337505-63-2
- Formula:C21H16ClN5OS
- Molecular Weight:421.90
IUPAC Name: N-(3-chlorophenyl)-2-((4-phenyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide
InChIKey: PFPSZGPAQFBVHZ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(Cl)=C1)CSC2=NN=C(C3=CC=NC=C3)N2C4=CC=CC=C4
Biological Activity: ASN-1377642 is a NK1 receptor antagonist with a Ki value of 251 nM. ASN-1377642 shows antitumor action in breast cancer cells with NK1R-Tr high expression[1][2].
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ASN-1377642 | ASN-1377642 is a NK1 receptor antagonist with a Ki value of 251 nM. ASN-1377642 shows antitumor action in breast cancer cells with NK1R-Tr high expression. | |||||||||||||||||||||
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References
- [1]. Zhou Y, et al. Roles of full-length and truncated neurokinin-1 receptors on tumor progression and distant metastasis in human breast cancer. Breast Cancer Res Treat. 2013 Jul;140(1):49-61. [Content Brief]
- [2]. Evers A, et al. Ligand-supported homology modeling of g-protein-coupled receptor sites: models sufficient for successful virtual screening. Angew Chem Int Ed Engl. 2004 Jan;43(2):248-51. [Content Brief]
