Antileishmanial agent-42 

Antileishmanial agent-42 is an antileishmanial agent. Antileishmanial agent-42 has favorable interactions with key active site residues (e.g., Ser63, Asn66/295/299) of adenosine kinase. Antileishmanial agent-42 exerts activity against promastigote and amastigote forms of L. amazonensis, L. braziliensis, L. infantum, and L. donovani^[1].

Antileishmanial agent-42 (Compound 5a) potently inhibits Leishmania amazonensis, L. braziliensis, L. infantum, and L. donovani promastigotes with IC₅₀ values of 0.95, 0.53, 0.8, and 0.82 μM, and exhibits low cytotoxicity to RAW 264.7 macrophages with a CC₅₀ of 110.57 μM, resulting in high selectivity indices from 116.4 to 208.6^[1].
Antileishmanial agent-42 (0.78-50 μM; 72 h) potently inhibits intracellular amastigotes of Leishmania amazonensis, L. braziliensis, L. infantum, and L. donovani in RAW 264.7 macrophages with IC₅₀ values of 0.65, 0.48, .52 and 0.61 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

375.42

C₂₂H₂₁N₃O₃

O=C1N(CC#CC(N2CCOCC2)C3=CC=CC=C3)C(C4=CC=CC=C4)=NO1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Maciel LG, et al. Insights into a new class of antileishmanial compounds: an in vitro and in silico study of 1,2,4-oxadiazol-5(4H)-one derivatives. Bioorg Chem. 2026 Jul 15;176:109839.