1. Protein Tyrosine Kinase/RTK
  2. Src
  3. iHCK-37

iHCK-37 (Synonyms: ASN05260065)

Cat. No.: HY-139147
Handling Instructions

iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research.

For research use only. We do not sell to patients.

iHCK-37 Chemical Structure

iHCK-37 Chemical Structure

CAS No. : 516478-09-4

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Description

iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research[1].

IC50 & Target

Ki: 0.22 μM (Hck)[1]

In Vitro

iHCK-37 (5.0-20 μM; 24 hours) exhibits a potent in vitro antiproliferative activity. The dose (μM) for growth inhibition (GI50) is 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562)[2].
iHCK-37 (3-9 μM; plus Erythropoietin) leads to a decrease in ERK, AKT and P70S6K phosphorylation of in lentivirus HCK silenced K562 and U937 cell lines[2].
iHCK-37 (3-9 μM) results in a decrease of p-HCK, p-ERK, p-AKT, p-70S6 in the cell line KG1a (AML/CD34+), in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U937, HL60, KG1a, HEL and K562 cells
Concentration: 5.0-20 μM
Incubation Time: 24 hours
Result: Exhibited a reduction of growth in a dose-dependent manner.
Molecular Weight

544.73

Formula

C₃₀H₃₂N₄O₂S₂

CAS No.
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Storage

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iHCK-37
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HY-139147
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