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Cat. No.: HY-144630

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diSPhMC-Asn-Pro-Val-PABC-MMAE

diSPhMC-Asn-Pro-Val-PABC-MMAE (compound 9) is a potent ADC Linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

CAS No.: 2893871-68-4
Formula: C₈₃H₁₁₅N₁₁O₁₆S₂
Molecular Weight:1587.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

diSPhMC-Asn-Pro-Val-PABC-MMAE Chemical Structure

CAS No.: 2893871-68-4

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Biological Activity

Description

diSPhMC-Asn-Pro-Val-PABC-MMAE (compound 9) is a potent ADC Linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

All Drug-Linker Conjugates for ADC Isoforms :

Chemical Information

CAS No. 2893871-68-4
Molecular Weight 1587.00
Formula C₈₃H₁₁₅N₁₁O₁₆S₂
SMILES

O=C(OCC1=CC=C(C=C1)NC([C@@H](NC([C@H]2N(CCC2)C([C@@H](NC(CCCCCN3C(C(SC4=CC=CC=C4)=C(C3=O)SC5=CC=CC=C5)=O)=O)CC(N)=O)=O)=O)C(C)C)=O)N([C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@H]([C@H](OC)CC(N6CCC[C@]6([C@@H]([C@H](C(N[C@@H]([C@@H](O)C7=CC=CC=C7)C)=O)C)OC)[H])=O)[C@H](CC)C)=O)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mohamed Amar IA, et al. Dual intra- and extracellular release of monomethyl auristatin E from a neutrophil elastase-sensitive antibody-drug conjugate. Eur J Med Chem. 2022 Feb 5;229:114063. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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