WDR27 - WD repeat domain 27 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 253769

About WDR27

This gene has 19 transcripts (splice variants), 211 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 1.4), ovary (RPKM 1.4) and 25 other tissues.

Summary

This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]

WDR27 Products (5)

mRNA Protein Name
NM_001202550.2 NP_001189479.1 WD repeat-containing protein 27 isoform 2
NM_001350623.2 NP_001337552.1 WD repeat-containing protein 27 isoform 3
NM_001350624.2 NP_001337553.1 WD repeat-containing protein 27 isoform 4
NM_001350625.2 NP_001337554.1 WD repeat-containing protein 27 isoform 4
NM_182552.5 NP_872358.4 WD repeat-containing protein 27 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR27 Protein Structure

WD40

WD40: WD domain, G-beta repeat (188 - 223)

WD40

WD40: WD domain, G-beta repeat (579 - 613)

WD40

WD40: WD domain, G-beta repeat (821 - 838)

(847 - 883)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 895 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 27

WDR27 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WDR27 A2RRH5 ASNS Homo sapiens P08243
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cranioectodermal Dysplasia 2

  • CED2

  • Sensenbrenner Syndrome 2

  • Dysplasia, Cranioectodermal, Type 2
Lacrimal Duct Obstruction

  • Blocked Lacrimal Canaliculus

  • Obstruction Of Lacrimal Canaliculus

  • Obstruction Of Lacrimal Ducts
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15771 WDR27 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WDR27 VGNC VGNC:50073
Canis familiaris WDR27 VGNC VGNC:55017
Macaca mulatta WDR27 VGNC VGNC:81192
Felis catus WDR27 VGNC VGNC:102547
Rattus norvegicus WDR27 RGD RGD:1309633
Mus musculus WDR27 MGD MGI:1918932
Others WDR27 NCBI