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製品番号: HY-129286

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ASN 05397535

ASN 05397535 is an anticancer agent. ASN 05397535 can be used in the research of colon adenocarcinoma and prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 601502-36-7
分子式: C₂₁H₁₆ClN₃O₃
分子量:393.83

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ASN 05397535 構造式

CAS 番号: 601502-36-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

ASN 05397535 is an anticancer agent. ASN 05397535 can be used in the research of colon adenocarcinoma and prostate cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	GI₅₀	<1 μM Compound: 49	Cytotoxicity in HEK293 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in HEK293 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
LNCaP	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human LNCAP cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human LNCAP cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
MDA-MB-231	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
U-937	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human U937 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human U937 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]

体外実験

ASN 05397535 exhibits almost no direct inhibitory activity against the ATP-binding sites of Aurora-A and Aurora-B^[1].
ASN 05397535 (10 μM) exhibits inhibitory activity against DU145 and HT-29, with GI₅₀ values of 32.95 μM and 1.03 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 601502-36-7
分子量 393.83
分子式 C₂₁H₁₆ClN₃O₃
SMILES

ClC=1C=CC2=NC(C=3C=CC=CC3O)=C(NCC4=CC=C5OCOC5=C4)N2C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Morshed MN. Identification of Aurora-A Inhibitors by Ligand and Structure-Based Virtual Screening. Mol Inform. 2014 May;33(5):369-81.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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