[Asn18] Endothelin-1 (swine, human)
[Asn18] Endothelin-1 swine, human is a structural analogue of Endothelin 1 (swine, human) (HY-P0202), with the Asp amino acid at position 18 mutated to Asn. Endothelin 1 (swine, human) is a synthetic peptide with human and porcine endothelin 1 sequences and is a potent endogenous vasoconstrictor.
For research use only. We do not sell to patients.
- CAS No.: 138716-98-0
- Formula: C109H160N26O31S5
- Molecular Weight:2490.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[Asn18] Endothelin-1 (swine, human) Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3615.gif "Click to View [Asn18] Endothelin-1 (swine, human) Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Endothelin‑1 is a potent vasoconstrictor peptide and regulator of blood flow, and plays an important role in elevating blood pressure in several experimental hypertension models. It has been shown to be critically involved in atherosclerosis, ischemic heart disease, and stroke[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 138716-98-0
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Molecular Weight 2490.92
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Formula C109H160N26O31S5
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Sequence
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asn-Ile-Ile-Trp (disulfide bridge:Cys1-Cys15, Cys3-Cys11)
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Sequence Shortening
CSCSSLMDKECVYFCHLNIIW (disulfide bridge:Cys1-Cys15, Cys3-Cys11)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[Asn18] Endothelin-1 (swine, human) Related Classifications
HY-P3615 Related Classifications
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