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Cat. No.: HY-W173361

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CBP/p300-IN-24

CBP/p300-IN-24 is a selective CBP bromodomain inhibitor with an IC₅₀ of 32 μM, showing selectivity over BRD4 BD-1 bromodomain. CBP/p300-IN-24 binds to the acetyl lysine binding pocket, forms hydrogen bonds with Asn1168 and a solvent-mediated hydrogen bond with Tyr1125, and forms hydrophobic interactions with Leu1120, Ile1122, and Val1174.

For research use only. We do not sell to patients.

CAS No.: 56369-21-2
Formula: C₁₁H₁₄N₂O
Molecular Weight:190.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CBP/p300-IN-24 Chemical Structure

CAS No.: 56369-21-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

BRD4 BD1

220 μM (IC₅₀)

All Histone Acetyltransferase Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

CBP/p300-IN-24 (compound 1) inhibits isolated BRD4 BD-1 bromodomain with an IC₅₀ of 220 μM^[1].
CBP/p300-IN-24 binds to the acetyl lysine binding pocket of the isolated CBP bromodomain, forming specific hydrogen bonding and hydrophobic interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 56369-21-2
Molecular Weight 190.25
Formula C₁₁H₁₄N₂O
SMILES

O=C1NC=2C=CC=CC2NC(C)(C)C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Taylor AM, et al. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). ACS Med Chem Lett. 2016;7(5):531-536. Published 2016 Mar 15. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols
Purity & Documentation
References

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CBP/p300-IN-24

All Histone Acetyltransferase Isoforms

All Epigenetic Reader Domain Isoforms