CBP/p300-IN-24
CBP/p300-IN-24 is a selective CBP bromodomain inhibitor with an IC50 of 32 μM, showing selectivity over BRD4 BD-1 bromodomain. CBP/p300-IN-24 binds to the acetyl lysine binding pocket, forms hydrogen bonds with Asn1168 and a solvent-mediated hydrogen bond with Tyr1125, and forms hydrophobic interactions with Leu1120, Ile1122, and Val1174.
For research use only. We do not sell to patients.
- CAS No.: 56369-21-2
- Formula: C11H14N2O
- Molecular Weight:190.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRD4 BD1 220 μM (IC50) |
CBP/p300-IN-24 (compound 1) inhibits isolated BRD4 BD-1 bromodomain with an IC50 of 220 μM[1].
CBP/p300-IN-24 binds to the acetyl lysine binding pocket of the isolated CBP bromodomain, forming specific hydrogen bonding and hydrophobic interactions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 56369-21-2
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Molecular Weight 190.25
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Formula C11H14N2O
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SMILES
O=C1NC=2C=CC=CC2NC(C)(C)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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