56369-21-2

CBP/p300-IN-24 Chemical Structure
56369-21-2

Chemical Structure

CBP/p300-IN-24

  • CAS No.: 56369-21-2
  • Formula:C11H14N2O
  • Molecular Weight:190.25

IUPAC Name: 4,4-dimethyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one

InChIKey: LHMWSVAJMJMOSV-UHFFFAOYSA-N

SMILES: O=C1NC=2C=CC=CC2NC(C)(C)C1

Biological Activity: CBP/p300-IN-24 is a selective CBP bromodomain inhibitor with an IC50 of 32 μM, showing selectivity over BRD4 BD-1 bromodomain. CBP/p300-IN-24 binds to the acetyl lysine binding pocket, forms hydrogen bonds with Asn1168 and a solvent-mediated hydrogen bond with Tyr1125, and forms hydrophobic interactions with Leu1120, Ile1122, and Val1174[1].

Cat. No. Product Name Purity Description Pricing
HY-W173361 		CBP/p300-IN-24 CBP/p300-IN-24 is a selective CBP bromodomain inhibitor with an IC50 of 32 μM, showing selectivity over BRD4 BD-1 bromodomain. CBP/p300-IN-24 binds to the acetyl lysine binding pocket, forms hydrogen bonds with Asn1168 and a solvent-mediated hydrogen bond with Tyr1125, and forms hydrophobic interactions with Leu1120, Ile1122, and Val1174.
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