56369-21-2
56369-21-2
Chemical Structure
CBP/p300-IN-24
- CAS No.: 56369-21-2
- Formula:C11H14N2O
- Molecular Weight:190.25
IUPAC Name: 4,4-dimethyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
InChIKey: LHMWSVAJMJMOSV-UHFFFAOYSA-N
SMILES: O=C1NC=2C=CC=CC2NC(C)(C)C1
Biological Activity: CBP/p300-IN-24 is a selective CBP bromodomain inhibitor with an IC50 of 32 μM, showing selectivity over BRD4 BD-1 bromodomain. CBP/p300-IN-24 binds to the acetyl lysine binding pocket, forms hydrogen bonds with Asn1168 and a solvent-mediated hydrogen bond with Tyr1125, and forms hydrophobic interactions with Leu1120, Ile1122, and Val1174[1].
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CBP/p300-IN-24 | CBP/p300-IN-24 is a selective CBP bromodomain inhibitor with an IC50 of 32 μM, showing selectivity over BRD4 BD-1 bromodomain. CBP/p300-IN-24 binds to the acetyl lysine binding pocket, forms hydrogen bonds with Asn1168 and a solvent-mediated hydrogen bond with Tyr1125, and forms hydrophobic interactions with Leu1120, Ile1122, and Val1174. | |||||||||||||||||||||
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