Keap1-Nrf2-IN-13
Based on 1 Customer Validation
Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers.
For research use only. We do not sell to patients.
- Purity: 96.77%
- CAS No.: 2456294-92-9
- Formula: C28H32N2O10S2
- Molecular Weight:620.69
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.15 μM (Keap1-Nrf2 PPI)[1]
Keap1-Nrf2-IN-13 (compound 21a, 0.5-50 μM) has inhibitory effect against Keap1-Nrf2 protein–protein interaction (PPI) with an IC50 value of 0.15 μM (fluorescence polarization (FP) assay)[1].
Keap1-Nrf2-IN-13 (0.1 mM, 90 min) has metabolic stability in the presence of human liver microsomes[1].
Keap1-Nrf2-IN-13 forms hydrogen bond interactions with the key polar residues (Asn414, Arg415, Arg483, Gln530), resulting in strong binding affinities to the Keap1 protein (docking assay)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2456294-92-9
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Appearance Solid
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Molecular Weight 620.69
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Formula C28H32N2O10S2
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Color White to off-white
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SMILES
O=S(N([C@@H](C)C(O)=O)CC1=CC=CC=C1CN([C@@H](C)C(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)(C3=CC=C(OC)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 300 mg/mL (483.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6111 mL | 8.0556 mL | 16.1111 mL | 40.2778 mL |
| 5 mM | 0.3222 mL | 1.6111 mL | 3.2222 mL | 8.0556 mL | |
| 10 mM | 0.1611 mL | 0.8056 mL | 1.6111 mL | 4.0278 mL | |
| 15 mM | 0.1074 mL | 0.5370 mL | 1.0741 mL | 2.6852 mL | |
| 20 mM | 0.0806 mL | 0.4028 mL | 0.8056 mL | 2.0139 mL | |
| 25 mM | 0.0644 mL | 0.3222 mL | 0.6444 mL | 1.6111 mL | |
| 30 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3426 mL | |
| 40 mM | 0.0403 mL | 0.2014 mL | 0.4028 mL | 1.0069 mL | |
| 50 mM | 0.0322 mL | 0.1611 mL | 0.3222 mL | 0.8056 mL | |
| 60 mM | 0.0269 mL | 0.1343 mL | 0.2685 mL | 0.6713 mL | |
| 80 mM | 0.0201 mL | 0.1007 mL | 0.2014 mL | 0.5035 mL | |
| 100 mM | 0.0161 mL | 0.0806 mL | 0.1611 mL | 0.4028 mL |
Keap1-Nrf2-IN-13 Related Classifications
HY-150579 Related Classifications
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