2456294-92-9

Keap1-Nrf2-IN-13 Chemical Structure
2456294-92-9

Chemical Structure

Keap1-Nrf2-IN-13

  • CAS No.: 2456294-92-9
  • Formula:C28H32N2O10S2
  • Molecular Weight:620.69

IUPAC Name: (2S,2'S)-2,2'-((1,2-phenylenebis(methylene))bis(((4-methoxyphenyl)sulfonyl)azanediyl))dipropionic acid

InChIKey: HTAPIMRLIHBYTM-PMACEKPBSA-N

SMILES: O=S(N([C@@H](C)C(O)=O)CC1=CC=CC=C1CN([C@@H](C)C(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)(C3=CC=C(OC)C=C3)=O

Biological Activity: Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers[1].

Cat. No. Product Name Purity Description Pricing
HY-150579 		Keap1-Nrf2-IN-13 96.77% Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers.
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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

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