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KN-93 hydrochloride

112 Cited Publications
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Based on 112 publication(s) in Google Scholar

KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.

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  • Pureté : 99.64%
  • CAS No.: 1956426-56-4
  • Formule: C26H30Cl2N2O4S
  • Masse moléculaire:537.50
  • Stockage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • KN-93 hydrochloride Chemical Structure
    KN-93 hydrochloride Chemical Structure
  • Experimental Validation Results for KN-93 hydrochloride
  • Experimental Validation Results for KN-93 hydrochloride
  • Experimental Validation Results for KN-93 hydrochloride
  • Experimental Validation Results for KN-93 hydrochloride
  • Experimental Validation Results for KN-93 hydrochloride
  • Experimental Validation Results for KN-93 hydrochloride
  • Experimental Validation Results for KN-93 hydrochloride
  • Experimental Validation Results for KN-93 hydrochloride
  • Experimental Validation Results for KN-93 hydrochloride
CAS No.: 1956426-56-4
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  • KN-93 hydrochloride Chemical Structure
    KN-93 hydrochloride Chemical Structure
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    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 28;10(1):357. [Abstract]

    Customer Validation
     BMMSCs isolated from femurs and tibias of 10-week-old male C57BL/6J mice were treated with CaMKII inhibitor KN-93 (10 μM) and/or Piezo1 activator Yoda1 (5 μM) for 2 hours. The mRNA level of Klf2 was determined by real-time PCR. n=5 for each group.

  • 1/16

    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 7;16(1):1429. [Abstract]

    Customer Validation
     Anti-PD−1 and CAMKII antagonist KN-93 (1 mg/kg; i.p.; twice a week for 3 weeks) treatment in mice bearing MC38 liver metastases. Tumor progression was monitored post-tumor cell inoculation using live animal bioluminescent imaging.

  • 1/16

    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 7;16(1):1429. [Abstract]

    Customer Validation
     Anti-PD-1 and CAMKII antagonist KN-93 (1 mg/kg; i.p.; twice a week for 3 weeks) treatment in mice bearing KPC liver metastases. Tumor progression was monitored post-tumor cell inoculation using live animal bioluminescent imaging.

  • 1/16

    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 7;16(1):1429. [Abstract]

    Customer Validation
     The mRNA expression levels of CXCL10, CCL4, and IL17D in tissues of MC3 and KPC liver metastases in each group. Mice were injected intraperitoneally with 100 μg anti-PD-1 antibody or 1 mg/kg KN-93, a combination of both, or IgG and vehicle control twice a week for 3 weeks.

  • 1/16

    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell. 2022 Jun 23;185(13):2354-2369.e17. [Abstract]

    Customer Validation
     HEK293T cells were cotransfected with ISRE firefly and Renilla reporters. Cells were treated with 2-fold dilutions of W7, KN-93 (2.5-20 μM), or TyrA9 30 min prior to the addition of IFNβ for 18 h.

  • 1/16

    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2020 Feb;41(2):218-228. [Abstract]

    Customer Validation
     HUVECs are pretreated with KN93 for 1 h, followed by ZYZ-803 (1 μM) for 30 min. Protein levels are assessed by Western blot.

  • 1/16

    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Diabetes. 2018 Sep;67(9):1748-1760. [Abstract]

    Customer Validation
     Immunoblotting analysis of PCK1, G6Pase, and phospho-CaMKIIγ proteins in NTG and HCTG hepatocytes in response to PGF2α and in the presence or absence of KN-93 treatment.

  • 1/16

    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Apr 12:9:362. [Abstract]

    Customer Validation
     MK 733-increased biotinylated α7nAChR protein is blocked by the addition of KN93 (P<0.01, n=6 mice).

  • 1/16

    KN-93 hydrochloride purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2018 Mar 15;364(2):198-207. [Abstract]

    Customer Validation
     Western blot analysis of β-catenin protein level in HEK 293T cells stimulated for 12h with rAGR2 (100 ng/mL) coupled with or without KN93 (10 μM).

  • KN-93 hydrochloride