OXA(17-33)
Based on 1 Customer Validation
OXA (17-33) (Orexin A (17-33) (human, mouse, rat, bovine)) is the shortest active orexin peptide that selectively targets OX1 (EC50=8.29 nM), with 23-fold selectivity for the OX1 receptor over the OX2 receptor. The activity of OXA (17-33) depends on the Tyr17, Leu20, Asn25, His26 residues and the spatial conformation of the α-helix. OXA (17-33) activates signaling pathways involving inositol-1,4,5-trisphosphate receptor (IP3R), phospholipase D (PL-D) and choline-Sigma-1R, thereby increasing the cytoplasmic Ca2+ level in nucleus accumbens neurons, an effect that is blocked by Sigma-1R antagonists. OXA (17-33) serves as an important biological probe for investigating the function of the OX1 receptor. OXA (17-33) can be modified via incorporation of mixed disulfide bonds of homocysteine and cysteamine, and is widely used in studies related to insomnia and narcolepsy.
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- 純度: 97.48%
- CAS 番号: 343268-91-7
- 分子式: C79H125N23O22
- 分子量:1748.98
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保管条件:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Orexin Receptor (OX Receptor) アイソフォーム固有の製品をすべて表示
MoreSigma Receptor アイソフォーム固有の製品をすべて表示
MorePhospholipase アイソフォーム固有の製品をすべて表示
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生物活性
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OX1 8.29 nM (EC50) |
OX2 187 nM (EC50) |
PLD1 |
Sigma 1 Receptor |
OXA(17-33) (0.1-100 nM) dose-dependently increases cytosolic calcium concentration in cultured nucleus accumbens neurons via activation of OX1 receptors, with a transient response observed at the 10 nM concentration[2].
OXA(17-33) (10 nM) increases cytosolic calcium concentration in cultured nucleus accumbens neurons in Ca2+-free saline via an IP3 receptor-dependent mechanism, with no contribution from endo-lysosomal calcium stores[2].
OXA(17-33) (10 nM) increases cytosolic calcium concentration in cultured nucleus accumbens neurons via a choline-Sigma-1R-dependent mechanism, as inhibition of PLD or antagonism of Sigma-1R reduces the magnitude of the response[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 343268-91-7
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性状 Solid
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分子量 1748.98
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分子式 C79H125N23O22
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Color White to off-white
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別名
Orexin A (17-33) (human, mouse, rat, bovine)
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配列
Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2
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シーケンスの短縮
YELLHGAGNHAAGILTL-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
H2O : ≥ 12.5 mg/mL (7.15 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. German NA, et al. Truncated Orexin Peptides: Structure-Activity Relationship Studies. ACS Med Chem Lett. 2013;4(12):1224-1227. [Content Brief]
[3]. Einsiedel J, et al. Development of disulfide-functionalized peptides covalently binding G protein-coupled receptors. Bioorg Med Chem. 2022;61:116720. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.5718 mL | 2.8588 mL | 5.7176 mL | 14.2940 mL |
| 5 mM | 0.1144 mL | 0.5718 mL | 1.1435 mL | 2.8588 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
OXA(17-33) 関連分類
HY-P1341 関連分類
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- OXA(17-33)
- 343268-91-7
- Orexin A (17-33) (human, mouse, rat, bovine)
- Orexin Receptor (OX Receptor)
- Sigma Receptor
- Phospholipase
- G protein-coupled receptor
- OX1 receptor
- Sigma-1R antagonists
- phospholipase D
- nucleus accumbens neurons
- CHO-RD-HGA16 cells
- inositol-1,4,5-trisphosphate receptors
- orexin peptide
- OX2 receptors
- choline-Sigma-1R
- Inhibitor
- inhibitor
- inhibit