1. GPCR/G Protein
  2. Orexin Receptor (OX Receptor)
  3. TCS-OX2-29

TCS-OX2-29 

Cat. No.: HY-100452 Purity: 99.18%
Handling Instructions

TCS-OX2-29 is a potent and selective OX2 receptor antagonist with IC50 of 40 nM. Displays >250-fold selectivity for OX2 over OX1.

For research use only. We do not sell to patients.

TCS-OX2-29 Chemical Structure

TCS-OX2-29 Chemical Structure

CAS No. : 372523-75-6

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Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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100 mg USD 1188 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

TCS-OX2-29 is a potent and selective OX2 receptor antagonist with IC50 of 40 nM. Displays >250-fold selectivity for OX2 over OX1. target: OX2 IC 50: 40 nM In vitro:TCS-OX2-29 shows selectivity for ion channels, and transporters (<30% inhibition at 10 μM), which includes G-protein coupled receptors associated with food intake including galanin and neuripeptide Y. [1] TCS-OX2-29 Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor. [2]

Molecular Weight

397.51

Formula

C₂₃H₃₁N₃O₃

CAS No.

372523-75-6

SMILES

CC(C)(C)[[email protected]](NCC1=CC=NC=C1)C(N2CC3=C(C=C(OC)C(OC)=C3)CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

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TCS-OX2-29
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HY-100452
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