OX₂ Receptor

OX₂ Receptor Related Products (21):

By Type:	Pan (7) Selective (12)
By Effects:	Agonists (6) Antagonists (15)

Cat. No.	Product Name	Effect	Purity

HY-16725

Lemborexant	Antagonist	99.92%
Lemborexant (E-2006) is a reversible, competitive and orally active dual antagonist of the orexin OX1 and OX2 receptors with IC₅₀ values of 6.1 nM and 2.6 nM, respectively.

HY-10895A

SB-334867 free base	Antagonist	99.89%
SB-334867 free base (SB334867A free base) is an excellent, selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pK_b=7.4), 100-fold over 5-HT_2B, 5-HT_2C with pK_i values of 5.4 and 5.3, respectively.

HY-10805

Almorexant	Antagonist	99.71%
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with K_d values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively.

HY-10805A

Almorexant hydrochloride	Antagonist	99.98%
Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with K_d values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively.

HY-109012

Seltorexant	Antagonist	99.62%
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pK_i values of 8.0 and 8.1 for human and rat OX2R).

HY-109012A

Seltorexant hydrochloride	Antagonist	99.90%
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pK_i values of 8.0 and 8.1 for human and rat OX2R).

HY-10900

TCS 1102	Antagonist	99.64%
TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively.

HY-100452

TCS-OX2-29	Antagonist	99.24%
TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX₂R) antagonist with an IC₅₀ value of 40 nM and a pK_I value of 7.5.

HY-19914

MK-1064	Antagonist	99.48%
MK-1064 is a selective and orally active OX₂R antagonist (K_i: 0.5 nM, IC₅₀: 18 nM).

HY-10898

SB-674042	Antagonist	99.84%
SB-674042 is a potent and selective non-peptide orexin OX₁ receptor antagonist (K_d=5.03 nM), exhibits 100-fold selectivity for OX₁ over OX₂ receptors with IC₅₀ values of 3.76 nM and 531 nM, respectively.

HY-108682

EMPA	Antagonist	99.69%
EMPA is a high-affinity, reversible and selective orexin OX₂ receptor antagonist.

HY-136181

YNT-185 dihydrochloride	Agonist	≥98.0%
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively.

HY-138695

Orexin 2 Receptor Agonist 2	Agonist	98.06%
Orexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16.

HY-101834

ACT-462206	Antagonist	99.60%
ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC₅₀s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively.

HY-108683

ACT-335827	Antagonist
ACT-335827 is a selective, orally active, brain-penetrant orexin type 1 receptor antagonist.

HY-P1340A

[Ala11,D-Leu15]-Orexin B(human) TFA	Agonist
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist.

HY-P1341

OXA(17-33)	Agonist	98.63%
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist.

HY-P1341A

OXA(17-33) TFA	Agonist
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist.

HY-146517

Orexin receptor antagonist 4	Antagonist
Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC₅₀ of 4.27 nM.

HY-P1340

[Ala11,D-Leu15]-Orexin B(human)	Agonist
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist.

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