1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. MK-1064

MK-1064 

Cat. No.: HY-19914 Purity: 99.97%
Handling Instructions

MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.

For research use only. We do not sell to patients.

MK-1064 Chemical Structure

MK-1064 Chemical Structure

CAS No. : 1207253-08-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 219 In-stock
Estimated Time of Arrival: December 31
1 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 336 In-stock
Estimated Time of Arrival: December 31
25 mg USD 660 In-stock
Estimated Time of Arrival: December 31
50 mg USD 960 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Publications Citing Use of MCE MK-1064

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Description

MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia. target: 2-SORA [1] In vivo: MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg/kg. [2]

Clinical Trial
Molecular Weight

461.90

Formula

C₂₄H₂₀ClN₅O₃

CAS No.

1207253-08-4

SMILES

O=C(C1=CC(C2=CC(Cl)=CN=C2)=CN=C1C3=NC=CC=C3)NCC4=NC(OC)=C(OC)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.25 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1650 mL 10.8249 mL 21.6497 mL
5 mM 0.4330 mL 2.1650 mL 4.3299 mL
10 mM 0.2165 mL 1.0825 mL 2.1650 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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KeyWords:

MK-1064 | MK1064 | MK 1064 | Orexin Receptor (OX Receptor) | Hypocretin Receptor | HCRT Receptor | Inhibitor | inhibitor | inhibit

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Product name:
MK-1064
Cat. No.:
HY-19914
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