1207253-08-4
1207253-08-4
Chemical Structure
MK-1064
- CAS No.: 1207253-08-4
- Formula:C24H20ClN5O3
- Molecular Weight:461.90
IUPAC Name: 5''-chloro-N-((5,6-dimethoxypyridin-2-yl)methyl)-[2,2':5',3''-terpyridine]-3'-carboxamide
InChIKey: CKTWQGHVNRYNCM-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=CC(Cl)=CN=C2)=CN=C1C3=NC=CC=C3)NCC4=NC(OC)=C(OC)C=C4
Biological Activity: MK-1064 is a selective and orally active OX2R antagonist (Ki: 0.5 nM, IC50: 18 nM). MK-1064 promotes sleep in vivo. MK-1064 can be used in the research of insomnia[1][3].
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MK-1064 | 99.95% | MK-1064 is a selective and orally active OX2R antagonist (Ki: 0.5 nM, IC50: 18 nM). MK-1064 promotes sleep in vivo. MK-1064 can be used in the research of insomnia. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.65
HY-12301MK-3697 -
Similarity Score 0.50
HY-149493IHMT-PI3K-455 -
Similarity Score 0.49
HY-76474BAY 61-3606 -
Similarity Score 0.49
HY-76474ABAY 61-3606 hydrochloride -
Similarity Score 0.48
HY-12083PPY-A -
Similarity Score 0.48
HY-14985BAY 61-3606 dihydrochloride -
Similarity Score 0.48
HY-132133Nav1.8-IN-1 -
Similarity Score 0.48
HY-109190Seralutinib -
Similarity Score 0.48
HY-126131Anti-TB agent 1 -
Explore the MedChemAI to find more analogs
References
- [1]. Roecker AJ et al. Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. ChemMedChem. 2014 Feb;9(2):311-22. [Content Brief]
- [3]. Laura A Grafe, et al. Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress. Neuroscience. 2017 Apr 21;348:313-323. [Content Brief]
