BAY 61-3606 hydrochloride
Based on 5 publication(s) in Google Scholar
BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
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- Pureté : 98.08%
- CAS No.: 1615197-10-8
- Formule: C20H19ClN6O3
- Masse moléculaire:426.86
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BAY 61-3606 hydrochloride
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Activité biologique
Description
Chemical Information
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CAS No. 1615197-10-8
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Appearance Solid
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Masse moléculaire 426.86
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Formule C20H19ClN6O3
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Color Light yellow to yellow
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SMILES
NC(C1=C(N=CC=C1)NC2=NC(C3=CC(OC)=C(C=C3)OC)=CC4=NC=CN24)=O.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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NPJ Precis Oncol
Siglec-14-LGALS3BP glycoimmune axis shapes tumor-associated macrophage polarization and confers poor outcome in colorectal cancer. [Abstract]2025 Dec 15;9(1):398. PMID: 41398201 -
Int J Mol Sci
A Combined Activity of Thrombin and P-Selectin Is Essential for Platelet Activation by Pancreatic Cancer Cells. [Abstract]2021 Mar 24;22(7):3323. PMID: 33805059 -
Pulm Pharmacol Ther
Evodiamine protects against lung ischemia-reperfusion injury by attenuating SYK-associated TLR4/NLRP3 inflammasome activation and ferroptosis-related injury signatures. [Abstract]2026 Jun:93:102421. PMID: 41951097 -
Hematology
Shikonin promotes ferroptosis though NSUN2-mediated m5C methylation modification of TFRC in acute myelocytic leukemia. [Abstract]2025 Dec;30(1):2495221. PMID: 40270446 -
Solvant et solubilité
In Vitro:
DMSO : 25 mg/mL (58.57 mM; ultrasonic and warming and heat to 160°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (252 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3427 mL | 11.7134 mL | 23.4269 mL | 58.5672 mL |
| 5 mM | 0.4685 mL | 2.3427 mL | 4.6854 mL | 11.7134 mL | |
| 10 mM | 0.2343 mL | 1.1713 mL | 2.3427 mL | 5.8567 mL | |
| 15 mM | 0.1562 mL | 0.7809 mL | 1.5618 mL | 3.9045 mL | |
| 20 mM | 0.1171 mL | 0.5857 mL | 1.1713 mL | 2.9284 mL | |
| 25 mM | 0.0937 mL | 0.4685 mL | 0.9371 mL | 2.3427 mL | |
| 30 mM | 0.0781 mL | 0.3904 mL | 0.7809 mL | 1.9522 mL | |
| 40 mM | 0.0586 mL | 0.2928 mL | 0.5857 mL | 1.4642 mL | |
| 50 mM | 0.0469 mL | 0.2343 mL | 0.4685 mL | 1.1713 mL |
BAY 61-3606 hydrochloride Related Classifications
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