BAY 61-3606 hydrochloride

Cat. No.: HY-76474A Pureza: 98.08%: Ficha de datos
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BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

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BAY 61-3606 hydrochloride Estructura química

No. CAS : 1615197-10-8

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 4 publication(s) in Google Scholar

Other Forms of BAY 61-3606 hydrochloride:

BAY 61-3606 Obtener un presupuesto

4 Publications Citing Use of MCE BAY 61-3606 hydrochloride

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Revisión del cliente

Descripciòn

Peso molecular

426.86

Fòrmula

C₂₀H₁₉ClN₆O₃

No. CAS

1615197-10-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

NC(C1=C(N=CC=C1)NC2=NC(C3=CC(OC)=C(C=C3)OC)=CC4=NC=CN24)=O.Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 25 mg/mL (58.57 mM; ultrasonic and warming and heat to 160°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3427 mL	11.7134 mL	23.4269 mL
5 mM	0.4685 mL	2.3427 mL	4.6854 mL
10 mM	0.2343 mL	1.1713 mL	2.3427 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.08%

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Ficha de datos (252 KB) SDS (252 KB)

COA (256 KB) HNMR (140 KB) RP-HPLC (246 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3427 mL	11.7134 mL	23.4269 mL	58.5672 mL
	5 mM	0.4685 mL	2.3427 mL	4.6854 mL	11.7134 mL
	10 mM	0.2343 mL	1.1713 mL	2.3427 mL	5.8567 mL
	15 mM	0.1562 mL	0.7809 mL	1.5618 mL	3.9045 mL
	20 mM	0.1171 mL	0.5857 mL	1.1713 mL	2.9284 mL
	25 mM	0.0937 mL	0.4685 mL	0.9371 mL	2.3427 mL
	30 mM	0.0781 mL	0.3904 mL	0.7809 mL	1.9522 mL
	40 mM	0.0586 mL	0.2928 mL	0.5857 mL	1.4642 mL
	50 mM	0.0469 mL	0.2343 mL	0.4685 mL	1.1713 mL