1. GPCR/G Protein
  2. Orexin Receptor (OX Receptor)

Orexin 2 Receptor Agonist 

Cat. No.: HY-19320 Purity: 99.93%
Handling Instructions

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.

For research use only. We do not sell to patients.

Orexin 2 Receptor Agonist Chemical Structure

Orexin 2 Receptor Agonist Chemical Structure

CAS No. : 1796565-52-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 186 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist. IC50 value: 23 nM (EC50) Target: Orexin 2 Receptor Orexin 2 Receptor Agonist shows not only potent activity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7044 mL 8.5222 mL 17.0445 mL
5 mM 0.3409 mL 1.7044 mL 3.4089 mL
10 mM 0.1704 mL 0.8522 mL 1.7044 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

586.7

Formula

C₃₂H₃₄N₄O₅S

CAS No.

1796565-52-0

SMILES

O=C(C1=CC=CC(C)=C1)NCCNC2=CC(NS(C3=C(OC)C=CC(C4=CC(C(N(C)C)=O)=CC=C4)=C3)(=O)=O)=CC=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Orexin 2 Receptor Agonist
Cat. No.:
HY-19320
Quantity: