Orexin A (human, rat, mouse) (Synonyms: Hypocretin-1 (human, rat, mouse))

Name: Orexin A (human, rat, mouse)
Brand: MedChemExpress
SKU: HY-106224
Rating: 5.0 (11 reviews)

Cat. No.: HY-106224 Purity: 97.53%: Data Sheet
COA

SDS
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Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 205640-90-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 11 publication(s) in Google Scholar

Other Forms of Orexin A (human, rat, mouse):

Orexin A (human, rat, mouse) TFA In-stock
Orexin A (human, rat, mouse) acetate In-stock

11 Publications Citing Use of MCE Orexin A (human, rat, mouse)

RT-PCR

In Vivo Efficacy Study

Histological Imaging/Staining

: Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 Nov;30(11):e70096. [Abstract]; Orexin A (human, rat, mouse) treatment attenuates hippocampal neuronal damage after CLP. Intranasal administration of 250 μg/kg of Orexin A (human, rat, mouse) drug, 2.5 μL per nostril, and 5.0 μL per mouse was used in this experiment. TUNEL staining showing neuronal apoptosis and quantification of TUNEL (green) with DAPI (blue) in the CA1 area of the hippocampus 7 days after CLP.

: Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 May 31:7:0384. [Abstract]; Schematic illustration of the effect of different concentrations of Orexin A (human, rat, mouse) on inflammatory factors expression in BV2. In addition, the mRNA expression of TNF-α, IL-6, IL-1β, and inducible nitric oxide synthase (iNOS) in different groups.

: Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]; Treatment with 250 µg/kg Orexin A (human, rat, mouse) increases 7-day survival. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).

: Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]; Treatment with 250 µg/kg Orexin A (human, rat, mouse) ameliorates cognitive and affective deficits in CLP-induced sepsis. Time in the central zone and distance of activity in the open field. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).

: Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]; Orexin A (human, rat, mouse) reduces inflammation by decreasing Rras expression and impeding activation of the RAS/MAPK pathway.

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OX₂ Receptor OX₁ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

OX₁ Receptor

OX₂ Receptor

In Vitro

Orexin A (human, rat, mouse) has high affinity for OX1R and OX2R, with 38 nM IC₅₀ and 34 nM EC₅₀ values in the the [Ca^2﹢]i transient assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Orexin A (human, rat, mouse) (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively^[2].
Orexin A (human, rat, mouse) (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female mice (mouse carrageenan-induced thermal hyperalgesia test)^[2]
Dosage:	3, 10 and 30 mg/kg
Administration:	i.v.; 5 min pre-test
Result:	Significantly increased the latency to response at 10 and 30 mg/kg.

Molecular Weight

3561.10

Formula

C₁₅₂H₂₄₃N₄₇O₄₄S₄

CAS No.

205640-90-0

Appearance

Solid

Color

White to off-white

Sequence

{Glp}-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

Sequence Shortening

{Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (28.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.2808 mL	1.4041 mL	2.8081 mL
5 mM	0.0562 mL	0.2808 mL	0.5616 mL
10 mM	0.0281 mL	0.1404 mL	0.2808 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (293 KB) SDS (252 KB)

COA (271 KB) LCMS (93 KB) Elemental Analysis Report (129 KB)

Handling Instructions (2659 KB)

References

[1]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Content Brief]

[2]. Bingham S, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 2001 May;92(1-2):81-90. [Content Brief]

[3]. Kaminski T, et al. Expression of orexin receptors in the pituitary. Vitam Horm. 2012;89:61-73. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.2808 mL	1.4041 mL	2.8081 mL	7.0203 mL
	5 mM	0.0562 mL	0.2808 mL	0.5616 mL	1.4041 mL
	10 mM	0.0281 mL	0.1404 mL	0.2808 mL	0.7020 mL
	15 mM	0.0187 mL	0.0936 mL	0.1872 mL	0.4680 mL
	20 mM	0.0140 mL	0.0702 mL	0.1404 mL	0.3510 mL
	25 mM	0.0112 mL	0.0562 mL	0.1123 mL	0.2808 mL

Orexin A (human, rat, mouse) Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orexin A (human, rat, mouse)205640-90-0Hypocretin-1 (human, rat, mouse)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptoraffinityG-protein-coupledreceptorfeedingbehaviornociceptiveanti-hyperalgesicInhibitorinhibitorinhibit

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Orexin A (human, rat, mouse) (Synonyms: Hypocretin-1 (human, rat, mouse))

Customer Review

Other Forms of Orexin A (human, rat, mouse):

Orexin A (human, rat, mouse) Related Antibodies

11 Publications Citing Use of MCE Orexin A (human, rat, mouse)

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Orexin Receptor (OX Receptor) Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Orexin A (human, rat, mouse) Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Orexin A (human, rat, mouse) Related Classifications

Keywords:

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