2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Orexin A (human, rat, mouse) TFA

Orexin A (human, rat, mouse) TFA  (Synonyms: Hypocretin-1 (human, rat, mouse) TFA)

Cat. No.: HY-106224A Purity: 98.13%
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Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

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Based on 11 publication(s) in Google Scholar

Other Forms of Orexin A (human, rat, mouse) TFA:

Orexin A (human, rat, mouse) TFA Related Antibodies

Top Publications Citing Use of Products

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 Nov;30(11):e70096.  [Abstract]

    Orexin A (human, rat, mouse) treatment attenuates hippocampal neuronal damage after CLP. Intranasal administration of 250 μg/kg of Orexin A (human, rat, mouse) drug, 2.5 μL per nostril, and 5.0 μL per mouse was used in this experiment. TUNEL staining showing neuronal apoptosis and quantification of TUNEL (green) with DAPI (blue) in the CA1 area of the hippocampus 7 days after CLP.

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 May 31:7:0384.  [Abstract]

    Schematic illustration of the effect of different concentrations of Orexin A (human, rat, mouse) on inflammatory factors expression in BV2. In addition, the mRNA expression of TNF-α, IL-6, IL-1β, and inducible nitric oxide synthase (iNOS) in different groups.

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131.  [Abstract]

    Treatment with 250 µg/kg Orexin A (human, rat, mouse) increases 7-day survival. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131.  [Abstract]

    Treatment with 250 µg/kg Orexin A (human, rat, mouse) ameliorates cognitive and affective deficits in CLP-induced sepsis. Time in the central zone and distance of activity in the open field. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131.  [Abstract]

    Orexin A (human, rat, mouse) reduces inflammation by decreasing Rras expression and impeding activation of the RAS/MAPK pathway.

    View All Orexin Receptor (OX Receptor) Isoform Specific Products:

    View All Isoforms
    OX2 Receptor OX1 Receptor

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    • Purity & Documentation

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    Description

    Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats[1][2][3].

    IC50 & Target

    OX1 Receptor

     

    OX2 Receptor

     

    In Vitro

    Orexin A (human, rat, mouse) TFA has high affinity for OX1R and OX2R, with 38 nM IC50 and 34 nM EC50 values in the the [Ca2﹢]i transient assay[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Orexin A (human, rat, mouse) TFA Related Antibodies
    In Vivo

    Orexin A (human, rat, mouse) TFA (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively[2].
    Orexin A (human, rat, mouse) TFA (3, 10 and 30 mg/kg; i.v.) is given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female mice (mouse carrageenan-induced thermal hyperalgesia test[2]
    Dosage: 3, 10 and 30 mg/kg
    Administration: i.v.; 5 min pre-test
    Result: Significantly increased the latency to response at 10 and 30 mg/kg.
    Molecular Weight

    3561.10 (free base)

    Formula

    C152H243N47O44S4.xC2HF3O2
    Appearance

    Solid

    Color

    White to off-white

    Sequence Shortening

    {Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (Need ultrasonic)

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    Purity & Documentation
    References
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    Orexin A (human, rat, mouse) TFA Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Orexin A (human, rat, mouse)Hypocretin-1 (human, rat, mouse)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptoraffinityG-protein-coupledreceptorfeedingbehaviornociceptiveanti-hyperalgesicInhibitorinhibitorinhibit

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