1. GPCR/G Protein Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Orexin A (human, rat, mouse) (TFA)

Orexin A (human, rat, mouse) (TFA)  (Synonyms: Hypocretin-1 (human, rat, mouse) (TFA))

Cat. No.: HY-106224A Purity: 98.33%
COA Handling Instructions

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

For research use only. We do not sell to patients.

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Orexin A (human, rat, mouse) (TFA) Chemical Structure

Orexin A (human, rat, mouse) (TFA) Chemical Structure

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1 mg USD 400 In-stock
5 mg USD 1600 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Orexin A (human, rat, mouse) (TFA):

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Description

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats[1][2].

IC50 & Target

OX1 Receptor

 

In Vitro

Orexin A (human, rat, mouse) TFA has high affinity for OX1R, with 38 nM IC50 and 34 nM EC50 values in the the [Ca2﹢]i transient assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Orexin A (human, rat, mouse) TFA (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively[2].
Orexin A (human, rat, mouse) TFA (3, 10 and 30 mg/kg; i.v.) is given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female mice (mouse carrageenan-induced thermal hyperalgesia test[2]
Dosage: 3, 10 and 30 mg/kg
Administration: i.v.; 5 min pre-test
Result: Significantly increased the latency to response at 10 and 30 mg/kg.
Formula

C152H243N47O44S4.xC2HF3O2

Appearance

Solid

Color

White to off-white

Sequence Shortening

{Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

Purity & Documentation
References
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Orexin A (human, rat, mouse) (TFA) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Orexin A (human, rat, mouse) (TFA)
Cat. No.:
HY-106224A
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