1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Orexin A (human, rat, mouse) (TFA)

Orexin A (human, rat, mouse) (TFA) 

Cat. No.: HY-106224A
Handling Instructions

Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse TFA has a role in the regulation of feeding behavior. Orexin A human, rat, mouse TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

For research use only. We do not sell to patients.

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Orexin A (human, rat, mouse) (TFA) Chemical Structure

Orexin A (human, rat, mouse) (TFA) Chemical Structure

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10 mM * 1 mL in DMSO USD 12936 In-stock
Estimated Time of Arrival: December 31
1 mg USD 400 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse TFA has a role in the regulation of feeding behavior. Orexin A human, rat, mouse TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats[1][2].

In Vitro

Orexin A human, rat, mouse TFA has high affinity for OX1R, with 38 nM IC50 and 34 nM EC50 values in the the [Ca2﹢]i transient assay[1].

In Vivo

Orexin A human, rat, mouse TFA (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively[2].
Orexin A human, rat, mouse TFA (3, 10 and 30 mg/kg; i.v.) is given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg[2].

Animal Model: Female mice (mouse carrageenan-induced thermal hyperalgesia test[2]
Dosage: 3, 10 and 30 mg/kg
Administration: i.v.; 5 min pre-test
Result: Significantly increased the latency to response at 10 and 30 mg/kg.
Molecular Weight

3675.12

Formula

C₁₅₄H₂₄₄N₄₇F₃O₄₆S₄

Sequence

{Glp}-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-IIE-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

Sequence Shortening

{Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Orexin A (human, rat, mouse) (TFA)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptoraffinityG-protein-coupledreceptorfeedingbehaviornociceptiveanti-hyperalgesicInhibitorinhibitorinhibit

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Orexin A (human, rat, mouse) (TFA)
Cat. No.:
HY-106224A
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