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Orexin A (human, rat, mouse) TFA

(Synonyms: Hypocretin-1 (human, rat, mouse) TFA)
12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

For research use only. We do not sell to patients.

  • Purity: 98.13%
  • Formula: C152H243N47O44S4.xC2HF3O2
  • Molecular Weight:3561.10 (free base)
  • Storage:

    Sealed storage, away from moisture.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Orexin A (human, rat, mouse) TFA Chemical Structure
    Orexin A (human, rat, mouse) TFA Chemical Structure
  • Experimental Validation Results for Orexin A (human, rat, mouse) TFA
  • Experimental Validation Results for Orexin A (human, rat, mouse) TFA
  • Experimental Validation Results for Orexin A (human, rat, mouse) TFA
  • Experimental Validation Results for Orexin A (human, rat, mouse) TFA
  • Experimental Validation Results for Orexin A (human, rat, mouse) TFA
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  • Orexin A (human, rat, mouse) TFA Chemical Structure
    Orexin A (human, rat, mouse) TFA Chemical Structure
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    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 May 31:7:0384. [Abstract]

    Customer Validation
     Schematic illustration of the effect of different concentrations of Orexin A (human, rat, mouse) on inflammatory factors expression in BV2. In addition, the mRNA expression of TNF-α, IL-6, IL-1β, and inducible nitric oxide synthase (iNOS) in different groups.

  • 1/16

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]

    Customer Validation
     Treatment with 250 µg/kg Orexin A (human, rat, mouse) increases 7-day survival. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).

  • 1/16

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]

    Customer Validation
     Treatment with 250 µg/kg Orexin A (human, rat, mouse) ameliorates cognitive and affective deficits in CLP-induced sepsis. Time in the central zone and distance of activity in the open field. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).

  • 1/16

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131. [Abstract]

    Customer Validation
     Orexin A (human, rat, mouse) reduces inflammation by decreasing Rras expression and impeding activation of the RAS/MAPK pathway.

  • 1/16

    Orexin A (human, rat, mouse) TFA purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 Nov;30(11):e70096. [Abstract]

    Customer Validation
     Orexin A (human, rat, mouse) treatment attenuates hippocampal neuronal damage after CLP. Intranasal administration of 250 μg/kg of Orexin A (human, rat, mouse) drug, 2.5 μL per nostril, and 5.0 μL per mouse was used in this experiment. TUNEL staining showing neuronal apoptosis and quantification of TUNEL (green) with DAPI (blue) in the CA1 area of the hippocampus 7 days after CLP.

  • Orexin A (human, rat, mouse) TFA