1. GPCR/G Protein
    Neuronal Signaling
  2. Orexin Receptor (OX Receptor)
  3. Almorexant

Almorexant (Synonyms: ACT 078573)

Cat. No.: HY-10805 Purity: 99.01%
Handling Instructions

Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.

For research use only. We do not sell to patients.

Almorexant Chemical Structure

Almorexant Chemical Structure

CAS No. : 871224-64-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 135 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 680 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Almorexant:

Top Publications Citing Use of Products

    Almorexant purchased from MCE. Usage Cited in: Oncotarget. 2018 Jan 9;9(6):6952-6967.

    Orexin-A and Almorexant promote tyrosine phosphorylation of SHP2/OX1R complex
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.

    IC50 & Target

    IC50: 1.3/0.7 nM(OX1/OX2 Receptor)

    Clinical Trial
    Molecular Weight

    512.56

    Formula

    C₂₉H₃₁F₃N₂O₃

    CAS No.

    871224-64-5

    SMILES

    CNC([[email protected]@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[[email protected]@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 46 mg/mL (89.75 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9510 mL 9.7550 mL 19.5099 mL
    5 mM 0.3902 mL 1.9510 mL 3.9020 mL
    10 mM 0.1951 mL 0.9755 mL 1.9510 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    • Molarity Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

    Keywords:

    AlmorexantACT 078573ACT078573ACT-078573Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorInhibitorinhibitorinhibit

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    Product Name:
    Almorexant
    Cat. No.:
    HY-10805
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