Almorexant (Standard)
Almorexant (Standard) is the analytical standard of Almorexant. This product is intended for research and analytical applications. Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
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- CAS. Nr.: 871224-64-5
- Formel: C29H31F3N2O3
- Molecular Weight:512.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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HY-10805
AlmorexantOrexin Receptor Antagonist -
HY-10805A
Almorexant hydrochlorideOrexin Receptor Antagonist -
HY-70068
SB-408124OX1 Receptor Antagonist -
HY-10900
TCS 1102OX Receptor Antagonist -
HY-10895
SB-334867OX1 Receptor Antagonist -
HY-10895A
SB-334867 free baseOX1 Antagonist -
HY-100452
TCS-OX2-29OX2R Antagonist -
HY-10898
SB-674042OX1 Receptor Antagonist -
HY-19320
Orexin 2 Receptor AgonistOX2R Agonist -
HY-76612
SB-408124 HydrochlorideOX1 Receptor Antagonist -
HY-12301
MK-3697OX2R Antagonist -
HY-106224
Orexin A (human, rat, mouse)Orexin Receptor Agonist
Product Information
Information
Anwendung
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS. Nr. 871224-64-5
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Molecular Weight 512.56
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Formel C29H31F3N2O3
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SMILES
CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O
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Synonyms
ACT 078573 (Standard)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Dayot S, et al. In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma. Oncotarget. 2018 Jan 9;9(6):6952-6967. [Content Brief]
[2]. Malherbe P, et al. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Mol Pharmacol. 2009 Sep;76(3):618-31. [Content Brief]
[3]. Black SW, et al. Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy. Sleep. 2013 Mar 1;36(3):325-36. [Content Brief]
[4]. Dietrich H, et al. Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant. Psychopharmacology (Berl). 2010 Oct;212(2):145-54. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Almorexant (Standard) Related Classifications
HY-10805R Related Classifications
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